Three-dimensional imaging of ventricular activation and electrograms from intracavitary recordings

Chenguang Liu, Paul A. Iaizzo, Bin He

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Three-dimensional (3-D) mapping of the ventricular activation is of importance to better understand the mechanisms and facilitate management of ventricular arrhythmias. The goal of this study was to develop and evaluate a 3-D cardiac electrical imaging (3DCEI) approach for imaging myocardial electrical activation from the intracavitary electrograms (EGs) and heart-torso geometry information over the 3-D volume of the heart. The 3DCEI was evaluated in a swine model undergoing intracavitary noncontact mapping (NCM). Each animals preoperative MRI data were acquired to construct the heart-torso model. NCM was performed with the Ensite 3000 system during acute ventricular pacing. Subsequent 3DCEI analyses were performed on the measured intracavitary EGs. The estimated initial sites (ISs) were compared to the precise pacing locations, and the estimated activation sequences (ASs) and EGs were compared to those recorded by the NCM system over the endocardial surface. In total, six ventricular sites from two pigs were paced. The averaged localization error of IS was 6.7 ± 2.6 mm. The endocardial ASs and EGs as a subset of the estimated 3-D solutions were consistent with those reconstructed from the NCM system. The present results demonstrate that the intracavitary-recording-based 3DCEI approach can well localize the sites of initiation and can obtain physiologically reasonable ASs as well as EGs in an in vivo setting under control/paced conditions. This study suggests the feasibility of tomographic imaging of 3-D ventricular activation and 3-D EGs from intracavitary recordings.

Original languageEnglish (US)
Article number5674073
Pages (from-to)868-875
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume58
Issue number4
DOIs
StatePublished - Apr 2011

Bibliographical note

Funding Information:
Manuscript received September 5, 2010; revised October 18, 2010; accepted November 15, 2010. Date of publication December 23, 2010; date of current version March 18, 2011. This work was supported in part by the NIH R01HL080093 and in part by the NSF CBET-0756331. The work of C. Liu was supported in part by a Doctoral Dissertation Fellowship from the Graduate School of the University of Minnesota. Asterisk indicates corresponding author.

Keywords

  • Activation imaging
  • cardiac electrical imaging
  • intracavitary recordings
  • intramural potential mapping

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