Three-dimensional image guidance for transcranial focused ultrasound therapy

Dalong Liu, Kyle Schaible, Walter Low, Emad S. Ebbini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations


A dual-mode ultrasound array (DMUA) imaging system for monitoring and delivery of transcranial focused ultrasound (tFUS) therapy is described. A DMUA prototype operating in the frequency range 2.4 - 4.2 MHz has been shown to generate tFUS beams at therapeutic levels in rat brains in vivo based on two-dimensional image guidance. Furthermore, real-time ultrasound thermography was shown to be feasible using beamformed DMUA imaging data. In this paper, we demonstrate the use of 3D DMUA imaging for guidance of tFUS beam to specific locations within the brain defined with reference to the bregma. The results demonstrate the ability of the DMUA prototype to clearly resolve the lambda, bregma and the medial suture lines, which allows the precise placement of the focal spot at the target location in a repeatable manner within a single experiment session and from one session to another. This has significant impact on tFUS applications requiring multiple treatments of the same target region, e.g. temporal lobe epilepsy.

Original languageEnglish (US)
Title of host publication2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781509011711
StatePublished - Jun 15 2017
Event14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia
Duration: Apr 18 2017Apr 21 2017

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Other14th IEEE International Symposium on Biomedical Imaging, ISBI 2017

Bibliographical note

Funding Information:
NIH Grants NS098781 and NS087887.

Publisher Copyright:
© 2017 IEEE.


  • Beamforming
  • Image-guided surgery
  • Neuromodulation
  • Synthetic-aperture Imaging
  • Ultrasound Thermography


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