Three-dimensional brain current source reconstruction from intra-cranial ECoG recordings

Yingchun Zhang, Wim van Drongelen, Michael Kohrman, Bin He

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


We have investigated 3-dimensional brain current density reconstruction (CDR) from intracranial electrocorticogram (ECoG) recordings by means of finite element method (FEM). The brain electrical sources are modeled by a current density distribution and estimated from the ECoG signals with the aid of a weighted minimum norm estimation algorithm. A series of computer simulations were conducted to evaluate the performance of ECoG-CDR by comparing with the scalp EEG based CDR results. The present computer simulation results indicate that the ECoG-CDR provides enhanced performance in localizing single dipole sources which are located in regions underneath the implanted subdural ECoG grids, and in distinguishing and imaging multiple separate dipole sources, in comparison to the CDR results as obtained from the scalp EEG under the same conditions. We have also demonstrated the applicability of the present ECoG-CDR method to estimate 3-dimensional current density distribution from the subdural ECoG recordings in a human epilepsy patient. Eleven interictal epileptiform spikes (seven from the frontal region and four from parietal region) in an epilepsy patient undergoing surgical evaluation were analyzed. The present promising results indicate the feasibility and applicability of the developed ECoG-CDR method of estimating brain sources from intracranial electrical recordings, with detailed forward modeling using FEM.

Original languageEnglish (US)
Pages (from-to)683-695
Number of pages13
Issue number2
StatePublished - Aug 15 2008

Bibliographical note

Funding Information:
The authors would like to thank Dr. Lei Ding, Christopher Wilke, and Zhongming Liu for useful discussions. This work was supported in part by NIH RO1EB007920, RO1EB00178, NSF BES-0411898, BES-0602957, and a grant from the Institute for Engineering in Medicine at the University of Minnesota, and the Minnesota Partnership for Biotechnology and Medical Genomics.


  • Brain source imaging
  • Current density reconstruction
  • ECoG
  • EEG
  • Electrophysiological neuroimaging
  • Epilepsy
  • Finite element method
  • Interictal spike
  • Intracranial recordings

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