Thiolsulfonate functionalized polystyrene resin: Preparation and application in the isolation and identification of electrophilic mutagens

Wu E, Robert M. Carlson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A new approach for isolation and identification of elecrtophilic mutagens from complex matrix was developed. Thiosulfonic anion was immobilized onto polystyrene beads and used as separation media. Potassium polystyryl-thiosulfonate, prepared from polystyrylsulfonyl chloride and KHS, was observed to selectively react with model electrophilic mutagens such as alkyl halides, α-chloroketones and α-chloroesters to produce polystyryl-thiosulfonic esters. After separation from other nonreactive organic compounds, the beads then reacted with ethanethiol to produce unsymmetrical ethyl disulfides which are easily detected by GC/MS. For one mutagenic compound, only one unsymmetrical disulfide was found to contain its structure part. Thus, the structure of the parent mutagens could be deduced from that of the unsymmetrical disulfides. The degree of functionalization of the potassium polystyryl-thiosulfonate resin was 1.11 mmol/g. Its reactivity was discussed and its recycling method was reported here.

Original languageEnglish (US)
Pages (from-to)1520-1527
Number of pages8
JournalJournal of Environmental Sciences
Volume19
Issue number12
DOIs
StatePublished - Dec 17 2007

Keywords

  • electrophilic mutagens
  • functionalized polystyrene
  • potassium polystyryl-thiosulfonate
  • unsymmetrical ethyl disulfides

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