Thiazolidinediones abrogate cervical cancer growth

Beverly R. Wuertz, Lindsay Darrah, Justin Wudel, Frank G. Ondrey

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Peroxisome proliferator-activated receptor gamma (PPAR γ) is activated by thiazolidinedione drugs (TZDs) and can promote anti-cancer properties. We used three TZDs (pioglitazone, rosiglitazone, and ciglitazone) to target cervical cancer cell lines and a nude mouse animal model. Each agent increased activation of PPAR γ, as judged by a luciferase reporter gene assay in three HPV-associated cell lines (CaSki, SiHa, and HeLa cells) while decreasing cellular proliferation in a dose-dependent manner. They also promoted Oil Red O accumulation in treated cell lines and upregulated the lipid differentiation marker adipsin. Interestingly, xenograft HeLa tumors in nude mice treated with 100 mg/kg/day pioglitazone exhibited decreased growth compared to control mice or mice treated with standard cervical chemotherapy. In conclusion, TZDs slow tumor cell growth in vitro and in vivo with decreases in cell proliferation and increases in PPAR γ and adipsin. These agents may be interesting treatments or treatment adjuncts for HPV-associated cancers or perhaps even precancerous conditions.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalExperimental Cell Research
Volume353
Issue number2
DOIs
StatePublished - Apr 15 2017

Keywords

  • Cervical cancer
  • Head and neck cancer
  • PPAR
  • Pioglitazone
  • Thiazolidinedione

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