Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems

M. Bretner; K. Felczak; J. M. Dzik; B. Golos; W. Rode; A. Drabikowska; J. Poznański; K. Krawiec; A. Piasek; D. Shugar; T. Kulikowski

doi:10.1080/07328319708006174

Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems

M. Bretner, K. Felczak, J. M. Dzik, B. Golos, W. Rode, A. Drabikowska, J. Poznański, K. Krawiec, A. Piasek, D. Shugar, T. Kulikowski

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Abstract

The synthesis of thiated nucleoside and nucleotide analogues, and determination of their structures, conformations, potential chemotherapeutic activities, and substrate/inhibitor properties in various enzyme systems, with emphasis on enzymes related to chemotherapeutic activities, are reported.

Original language	English (US)
Pages (from-to)	1295-1299
Number of pages	5
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	7-9
DOIs	https://doi.org/10.1080/07328319708006174
State	Published - 1997
Externally published	Yes

Bibliographical note

Funding Information:
Supported by the State Committee for Scientific Research (Grants No. 662539203p/O 1, 0071/P2/9203, and 4P05F0301 lpO1) REFERENCES 1. Felczak, K.; Bretner, M.; Kulikowski, T.; Shugar, D. Nucleosides Nucleotides, 1993, 12, 245. 2. Bretner, M.; Kuhkowski, T.; Duk, J.M.; Bahnska, M.; Rode, W. ; Shugar, D. J. Med. Chem. 1993,36,3611 3. DUk, J.M.; Bretner, M.; Kulikowski, T.; Golos, B.; Jarmula, A.; Poznanslu, J.; Rode, W.; Shugar, D. Biochim Biophys. Actu 1996, 1293, 1. 4. Duk, J.M.; Zielinski, Z.; Ciesla, J.; Bretner, M.; Kulikowslu, T.; Shugar, D.; Bertino, J.R.; Rode, W. Riochem. Biophys. Res. Commun. 1993, 195, 1301. 5. Kalman, T.I.; Bloch, A.; Szekeres, G.L.; Bardos, T. J. Biochem. Biophys. Res. Commun. 1973, 55,210. 6. Liu, L.; Santi, D.V. Biochim. Biophys. Acta 1994, 1209, 89.

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Bretner, M., Felczak, K., Dzik, J. M., Golos, B., Rode, W., Drabikowska, A., Poznański, J., Krawiec, K., Piasek, A., Shugar, D., & Kulikowski, T. (1997). Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems. Nucleosides and Nucleotides, 16(7-9), 1295-1299. https://doi.org/10.1080/07328319708006174

Bretner, M, Felczak, K, Dzik, JM, Golos, B, Rode, W, Drabikowska, A, Poznański, J, Krawiec, K, Piasek, A, Shugar, D & Kulikowski, T 1997, 'Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems', Nucleosides and Nucleotides, vol. 16, no. 7-9, pp. 1295-1299. https://doi.org/10.1080/07328319708006174

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title = "Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems",

abstract = "The synthesis of thiated nucleoside and nucleotide analogues, and determination of their structures, conformations, potential chemotherapeutic activities, and substrate/inhibitor properties in various enzyme systems, with emphasis on enzymes related to chemotherapeutic activities, are reported.",

author = "M. Bretner and K. Felczak and Dzik, {J. M.} and B. Golos and W. Rode and A. Drabikowska and J. Pozna{\'n}ski and K. Krawiec and A. Piasek and D. Shugar and T. Kulikowski",

note = "Funding Information: Supported by the State Committee for Scientific Research (Grants No. 662539203p/O 1, 0071/P2/9203, and 4P05F0301 lpO1) REFERENCES 1. Felczak, K.; Bretner, M.; Kulikowski, T.; Shugar, D. Nucleosides Nucleotides, 1993, 12, 245. 2. Bretner, M.; Kuhkowski, T.; Duk, J.M.; Bahnska, M.; Rode, W. ; Shugar, D. J. Med. Chem. 1993,36,3611 3. DUk, J.M.; Bretner, M.; Kulikowski, T.; Golos, B.; Jarmula, A.; Poznanslu, J.; Rode, W.; Shugar, D. Biochim Biophys. Actu 1996, 1293, 1. 4. Duk, J.M.; Zielinski, Z.; Ciesla, J.; Bretner, M.; Kulikowslu, T.; Shugar, D.; Bertino, J.R.; Rode, W. Riochem. Biophys. Res. Commun. 1993, 195, 1301. 5. Kalman, T.I.; Bloch, A.; Szekeres, G.L.; Bardos, T. J. Biochem. Biophys. Res. Commun. 1973, 55,210. 6. Liu, L.; Santi, D.V. Biochim. Biophys. Acta 1994, 1209, 89.",

year = "1997",

doi = "10.1080/07328319708006174",

language = "English (US)",

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AU - Dzik, J. M.

AU - Golos, B.

AU - Rode, W.

AU - Drabikowska, A.

AU - Poznański, J.

AU - Krawiec, K.

AU - Piasek, A.

AU - Shugar, D.

AU - Kulikowski, T.

N1 - Funding Information: Supported by the State Committee for Scientific Research (Grants No. 662539203p/O 1, 0071/P2/9203, and 4P05F0301 lpO1) REFERENCES 1. Felczak, K.; Bretner, M.; Kulikowski, T.; Shugar, D. Nucleosides Nucleotides, 1993, 12, 245. 2. Bretner, M.; Kuhkowski, T.; Duk, J.M.; Bahnska, M.; Rode, W. ; Shugar, D. J. Med. Chem. 1993,36,3611 3. DUk, J.M.; Bretner, M.; Kulikowski, T.; Golos, B.; Jarmula, A.; Poznanslu, J.; Rode, W.; Shugar, D. Biochim Biophys. Actu 1996, 1293, 1. 4. Duk, J.M.; Zielinski, Z.; Ciesla, J.; Bretner, M.; Kulikowslu, T.; Shugar, D.; Bertino, J.R.; Rode, W. Riochem. Biophys. Res. Commun. 1993, 195, 1301. 5. Kalman, T.I.; Bloch, A.; Szekeres, G.L.; Bardos, T. J. Biochem. Biophys. Res. Commun. 1973, 55,210. 6. Liu, L.; Santi, D.V. Biochim. Biophys. Acta 1994, 1209, 89.

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Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems

Abstract

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