Thiated pyrimidine deoxynucleoside analogues, potential chemotherapeutic agents, and substrates/inhibitors in various enzyme systems

M. Bretner, K. Felczak, J. M. Dzik, B. Golos, W. Rode, A. Drabikowska, J. Poznański, K. Krawiec, A. Piasek, D. Shugar, T. Kulikowski

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8 Scopus citations

Abstract

The synthesis of thiated nucleoside and nucleotide analogues, and determination of their structures, conformations, potential chemotherapeutic activities, and substrate/inhibitor properties in various enzyme systems, with emphasis on enzymes related to chemotherapeutic activities, are reported.

Original languageEnglish (US)
Pages (from-to)1295-1299
Number of pages5
JournalNucleosides and Nucleotides
Volume16
Issue number7-9
DOIs
StatePublished - 1997
Externally publishedYes

Bibliographical note

Funding Information:
Supported by the State Committee for Scientific Research (Grants No. 662539203p/O 1, 0071/P2/9203, and 4P05F0301 lpO1) REFERENCES 1. Felczak, K.; Bretner, M.; Kulikowski, T.; Shugar, D. Nucleosides Nucleotides, 1993, 12, 245. 2. Bretner, M.; Kuhkowski, T.; Duk, J.M.; Bahnska, M.; Rode, W. ; Shugar, D. J. Med. Chem. 1993,36,3611 3. DUk, J.M.; Bretner, M.; Kulikowski, T.; Golos, B.; Jarmula, A.; Poznanslu, J.; Rode, W.; Shugar, D. Biochim Biophys. Actu 1996, 1293, 1. 4. Duk, J.M.; Zielinski, Z.; Ciesla, J.; Bretner, M.; Kulikowslu, T.; Shugar, D.; Bertino, J.R.; Rode, W. Riochem. Biophys. Res. Commun. 1993, 195, 1301. 5. Kalman, T.I.; Bloch, A.; Szekeres, G.L.; Bardos, T. J. Biochem. Biophys. Res. Commun. 1973, 55,210. 6. Liu, L.; Santi, D.V. Biochim. Biophys. Acta 1994, 1209, 89.

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