@inproceedings{7dd297e964a34837a419e8e87e7b4782,
title = "Thermal therapy in the dunning AT-1 prostate tumor using a wet electrode RF probe",
abstract = "The effect of supraphysiological thermal therapy on tissue viability was investigated in an AT-1 Dunning rat prostate tumor model. After a thermal protocol was performed with concurrent temperature measurements, an in vivo-in vitro assay was used to assess cellular survival based on known thermal history and tetrazolium dye (TTC) and histology was used to evaluate overall tissue response 1, 3 and 7 days post ablation. The cellular study showed that survival gradually dropped to 0 with an increase in predicted injury (Ω) from 0.1 to 1. TTC analysis showed significant drop in enzyme activity and morphometry of histology revealed a significant increase in coagulative necrosis (p<0.01 for both studies) after each of 1, 3 and 7 days compared to sham tissue. These results show that controlled thermal destruction can be obtained in AT-1 prostate tumor using thermal therapy with no cellular survival at temperatures >47 °C for times≥a minute.",
author = "S. Bhowmick and L. Lulloff and Swanlund, \{D. J.\} and Coad, \{J. E.\} and Hoey, \{M. F.\} and Bischof, \{John C\}",
year = "1999",
month = dec,
day = "1",
language = "English (US)",
isbn = "0780356756",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
note = "Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) ; Conference date: 13-10-1999 Through 16-10-1999",
}