Thermal therapy in the dunning AT-1 prostate tumor using a wet electrode RF probe

S. Bhowmick, L. Lulloff, D. J. Swanlund, J. E. Coad, M. F. Hoey, John C Bischof

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of supraphysiological thermal therapy on tissue viability was investigated in an AT-1 Dunning rat prostate tumor model. After a thermal protocol was performed with concurrent temperature measurements, an in vivo-in vitro assay was used to assess cellular survival based on known thermal history and tetrazolium dye (TTC) and histology was used to evaluate overall tissue response 1, 3 and 7 days post ablation. The cellular study showed that survival gradually dropped to 0 with an increase in predicted injury (Ω) from 0.1 to 1. TTC analysis showed significant drop in enzyme activity and morphometry of histology revealed a significant increase in coagulative necrosis (p<0.01 for both studies) after each of 1, 3 and 7 days compared to sham tissue. These results show that controlled thermal destruction can be obtained in AT-1 prostate tumor using thermal therapy with no cellular survival at temperatures >47 °C for times≥a minute.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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