Thermal damage prediction for collagenous tissues part I

A clinically relevant numerical simulation incorporating heating rate dependent denaturation

Alptekin Aksan, John J. McGrath, David S. Nielubowicz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Subablative thermotherapy is frequently used for the treatment of joint instability related diseases. In this therapy, mechanically deformed collagenous tissues are thermally shrunk and the stability of the tissue is re-established. In this research, the thermal damage fields generated by three different clinical heating modalities (monopolar and bipolar radio frequency and Ho:YAG laser) are compared numerically using finite element analysis. The heating rate dependent denaturation characteristics of collagenous tissues are incorporated into the model using experimental data from in vitro experimentation with rabbit patellar tendons. It is shown that there are significant differences among the thermal damage profiles created by these modalities, explaining the main reason for the discrepancies reported in the literature in terms of the efficacy and safety of each modality. In the complementary paper, the accuracy of the model presented here is verified by in vitro experimentation with a model collagenous tissue and by quantifying the denaturation-induced birefringence change using Optical Coherence Tomography and Magnetic Resonance Imaging.

Original languageEnglish (US)
Pages (from-to)85-97
Number of pages13
JournalJournal of Biomechanical Engineering
Volume127
Issue number1
DOIs
StatePublished - Feb 1 2005

Fingerprint

Denaturation
Heating rate
Heating
Hot Temperature
Tissue
Computer simulation
Birefringence
Joint Instability
Patellar Ligament
Finite Element Analysis
Induced Hyperthermia
Optical tomography
Tendons
Solid-State Lasers
Optical Coherence Tomography
Radio
Theoretical Models
Magnetic Resonance Imaging
Rabbits
Safety

Cite this

Thermal damage prediction for collagenous tissues part I : A clinically relevant numerical simulation incorporating heating rate dependent denaturation. / Aksan, Alptekin; McGrath, John J.; Nielubowicz, David S.

In: Journal of Biomechanical Engineering, Vol. 127, No. 1, 01.02.2005, p. 85-97.

Research output: Contribution to journalArticle

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