Therapy with red blood cells decreases hyperoxic pulmonary injury

J. R. Hoidal, B. S. Van Asbeck, J. Mann, Harry S Jacob, T. P. Kennedy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Results of attempts to ameliorate hyperoxic pulmonary injury using novel systems for delivery of antioxidant enzymes are reviewed. Intratracheal insufflation of either liposome encapsulated superoxide dismutase or encapsulated catalase increased levels of enzyme activities in rat lung homogenates and prevented lethal effects of an atmosphere of oxygen. Intact erythrocytes placed in the tracheobronchial tree of rats also dramatically improved survival in hyperoxia. Recyclable glutathione appeared to be the constituent of erythrocytes, which was responsible for the protection. In rabbits, erythrocytes also protected from oxidant-mediated ischemic-reoxygenation lung injury. These studies suggest a possible role for erythrocytes as biologic packets of antioxidant enzymes.

Original languageEnglish (US)
Pages (from-to)977-985
Number of pages9
JournalExperimental Lung Research
Volume14
Issue numberS1
DOIs
StatePublished - Jan 1 1988

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Lung Injury
Rats
Blood
Antioxidants
Erythrocytes
Cells
Enzyme activity
Enzymes
Oxidants
Liposomes
Catalase
Superoxide Dismutase
Glutathione
Oxygen
Insufflation
Hyperoxia
Therapeutics
Atmosphere
Rabbits
Lung

Cite this

Therapy with red blood cells decreases hyperoxic pulmonary injury. / Hoidal, J. R.; Van Asbeck, B. S.; Mann, J.; Jacob, Harry S; Kennedy, T. P.

In: Experimental Lung Research, Vol. 14, No. S1, 01.01.1988, p. 977-985.

Research output: Contribution to journalArticle

Hoidal, J. R. ; Van Asbeck, B. S. ; Mann, J. ; Jacob, Harry S ; Kennedy, T. P. / Therapy with red blood cells decreases hyperoxic pulmonary injury. In: Experimental Lung Research. 1988 ; Vol. 14, No. S1. pp. 977-985.
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