TY - JOUR
T1 - Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis
AU - Martorelli De Lima, Antonio Fernando
AU - Cury, Cmila Cristina
AU - Palioto, Daniela Bazan
AU - Duro, Adhemar Mendes
AU - Da Silva, Robert Carvalho
AU - Wolff, Larry F.
PY - 2004/8
Y1 - 2004/8
N2 - Objectives: The purpose of this study was to evaluate the effect of subgingival administration of doxycycline as an adjunct to periodontal therapy in type 1 diabetes mellitus (DM) patients. Material and methods: Twenty-two paired periodontal defects ≥5.0 mm were treated in 11 patients (35-55 years old). After initial therapy the sites were randomly assigned into test (scaling and root planing+subgingival administration of 10% doxycycline hyelate gel) or control (scaling and root planing+subgingival placebo gel) groups. The clinical parameters of clinical attachment level (CAL), probing depth (PD) and gingival margin level (GML) for recession determination were assessed at baseline, after 6 weeks, and 6, 9 and 12 months, using a computerized probe. Data were statistically evaluated using Duncan and F tests. Results: Between study group comparisons indicated PD reduction and CAL gain were greater in the test group than in the control group at 6 weeks and 6, 9 and 12 months but only statistically significant at 12 months (p <0.05). Within study group comparisons indicated statistically significant differences were found for CAL and PD values favouring the adjunctive doxycycline group from baseline to 6 weeks and 6, 9 and 12 months (p <0.05). Conclusions: These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients.
AB - Objectives: The purpose of this study was to evaluate the effect of subgingival administration of doxycycline as an adjunct to periodontal therapy in type 1 diabetes mellitus (DM) patients. Material and methods: Twenty-two paired periodontal defects ≥5.0 mm were treated in 11 patients (35-55 years old). After initial therapy the sites were randomly assigned into test (scaling and root planing+subgingival administration of 10% doxycycline hyelate gel) or control (scaling and root planing+subgingival placebo gel) groups. The clinical parameters of clinical attachment level (CAL), probing depth (PD) and gingival margin level (GML) for recession determination were assessed at baseline, after 6 weeks, and 6, 9 and 12 months, using a computerized probe. Data were statistically evaluated using Duncan and F tests. Results: Between study group comparisons indicated PD reduction and CAL gain were greater in the test group than in the control group at 6 weeks and 6, 9 and 12 months but only statistically significant at 12 months (p <0.05). Within study group comparisons indicated statistically significant differences were found for CAL and PD values favouring the adjunctive doxycycline group from baseline to 6 weeks and 6, 9 and 12 months (p <0.05). Conclusions: These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients.
KW - Doxycycline local delivery
KW - Periodontal therapy
KW - Scaling and root planing
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U2 - 10.1111/j.0303-6979.2004.00576.x
DO - 10.1111/j.0303-6979.2004.00576.x
M3 - Article
C2 - 15257743
AN - SCOPUS:4143135139
SN - 0303-6979
VL - 31
SP - 648
EP - 653
JO - Journal of clinical periodontology
JF - Journal of clinical periodontology
IS - 8
ER -