Therapies for ventricular arrhythmias: Future directions

Ali A. Sovari, Abraham G. Kocheril, Samuel C. Dudley

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Current antiarrhythmic therapies, implantable defibrillators and catheter ablations have certain limitations for treatment of complex arrhythmias such as ventricular fibrillation and therefore new approaches for ventricular arrhythmia therapy are required. A review of the limitations of current treatment modalities can provide some guidance for designing new treatments. The major limitation of all currently available arrhythmia therapies is the fact that they often do not address the underlying pathologies which resulted in dysrhythmia. Some potential upstream therapeutic targets based on the current experimental and clinical studies include angiotensin, oxidative stress, myocardial fibrosis, myofilament Ca2+ sensitivity, increasing sodium current and micro RNAs. Search for better understanding of the mechanisms of complex arrhythmias should continue in order to design more effective antiarrhythmic treatments.

Original languageEnglish (US)
Title of host publicationVentricular Arrhythmia
Subtitle of host publicationFrom Principles to Patients
PublisherNova Science Publishers, Inc.
Pages285-300
Number of pages16
ISBN (Print)9781620815403
StatePublished - Feb 1 2013

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