Therapeutic potential of mesenchymal stem cells for severe acute lung injury

Michael A. Matthay, B. Taylor Thompson, Elizabeth J. Read, David H. McKenna, Kathleen D. Liu, Carolyn S. Calfee, Jae Woo Lee

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSC) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardial infarction, and more recently, acute lung injury (ALI). This article provides a brief review of the biologic qualities of MSC that make them suitable for the treatment of human diseases, as well as the experimental data that provide support for their potential efficacy for critically ill patients with acute respiratory failure from ALI. The article then discusses which patients with ALI might be the best candidates for cell-based therapy and provides a template for the regulatory and practical steps that will be required to test allogeneic human MSC in patients with severe ALI. There is a dual focus on how to design trials for testing both safety and efficacy.

Original languageEnglish (US)
Pages (from-to)965-972
Number of pages8
JournalCHEST
Volume138
Issue number4
DOIs
StatePublished - Oct 1 2010

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