Therapeutic plasma exchange in neuromyelitis optica

A case series

Shanna M. Morgan, Nicole D Zantek, Adam Carpenter

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Neuromyelitis optica (NMO) is a relapsing inflammatory disease of the central nervous system that predominantly affects the spinal cord and optic nerves. The clinical hallmark of the disease is a step-wise deterioration of visual and spinal cord function. This study reviews patients with steroid resistant relapsing NMO presenting for therapeutic plasma exchange (TPE) at our institution from December 2005 to December 2012. A total of five patients were treated with single volume TPE. Both subjective and objective clinical response to TPE was estimated by three different sources (the patient, a Transfusion Medicine physician, and the treating Neurologist) with the patient and Transfusion Medicine physician's final assessment of response made at the time of the last TPE in the series and the treating neurologist's assessment of response made at the time of the next neurological exam after the last TPE. A total of 17 TPE series were performed with the average course of therapy being three series (ranged 1-5) with five TPE (ranged 3-7) per series. All patients demonstrated improvement with each series of TPE and all procedures were well tolerated with only transient and well-described reactions all of which were successfully resolved with minor or no sequelae.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalJournal of Clinical Apheresis
Volume29
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Neuromyelitis Optica
Plasma Exchange
Transfusion Medicine
Therapeutics
Spinal Cord
Physicians
Spinal Nerves
Central Nervous System Diseases
Optic Nerve
Steroids

Keywords

  • apheresis
  • Devic's disease
  • optic neuritis

Cite this

Therapeutic plasma exchange in neuromyelitis optica : A case series. / Morgan, Shanna M.; Zantek, Nicole D; Carpenter, Adam.

In: Journal of Clinical Apheresis, Vol. 29, No. 3, 01.01.2014, p. 171-177.

Research output: Contribution to journalReview article

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