Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis

David M. Troendle, Douglas S. Fishman, Bradley A. Barth, Matthew J. Giefer, Tom K. Lin, Quin Y. Liu, Maisam Abu-El-Haija, Melena D. Bellin, Peter R. Durie, Steven D. Freedman, Cheryl Gariepy, Tanja Gonska, Melvin B. Heyman, Ryan Himes, Sohail Z. Husain, Soma Kumar, Mark E. Lowe, Veronique D. Morinville, Chee Y. Ooi, Joseph Palermo & 6 others John F. Pohl, Sarah Jane Schwarzenberg, Steven Werlin, Michael Wilschanski, M. Bridget Zimmerman, Aliye Uc

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods. Results: One hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P > 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP. Conclusions: Therapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

Original languageEnglish (US)
Pages (from-to)764-769
Number of pages6
JournalPancreas
Volume46
Issue number6
DOIs
StatePublished - Jan 1 2017

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Endoscopic Retrograde Cholangiopancreatography
Chronic Pancreatitis
Pancreatitis
Pediatrics
Therapeutics
Hispanic Americans
Longitudinal Studies
Physicians

Keywords

  • Bile ducts
  • Bile stent
  • Children
  • Endotherapy
  • Pancreatic ducts
  • Pancreatic stent

Cite this

Troendle, D. M., Fishman, D. S., Barth, B. A., Giefer, M. J., Lin, T. K., Liu, Q. Y., ... Uc, A. (2017). Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis. Pancreas, 46(6), 764-769. https://doi.org/10.1097/MPA.0000000000000848

Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis. / Troendle, David M.; Fishman, Douglas S.; Barth, Bradley A.; Giefer, Matthew J.; Lin, Tom K.; Liu, Quin Y.; Abu-El-Haija, Maisam; Bellin, Melena D.; Durie, Peter R.; Freedman, Steven D.; Gariepy, Cheryl; Gonska, Tanja; Heyman, Melvin B.; Himes, Ryan; Husain, Sohail Z.; Kumar, Soma; Lowe, Mark E.; Morinville, Veronique D.; Ooi, Chee Y.; Palermo, Joseph; Pohl, John F.; Schwarzenberg, Sarah Jane; Werlin, Steven; Wilschanski, Michael; Zimmerman, M. Bridget; Uc, Aliye.

In: Pancreas, Vol. 46, No. 6, 01.01.2017, p. 764-769.

Research output: Contribution to journalArticle

Troendle, DM, Fishman, DS, Barth, BA, Giefer, MJ, Lin, TK, Liu, QY, Abu-El-Haija, M, Bellin, MD, Durie, PR, Freedman, SD, Gariepy, C, Gonska, T, Heyman, MB, Himes, R, Husain, SZ, Kumar, S, Lowe, ME, Morinville, VD, Ooi, CY, Palermo, J, Pohl, JF, Schwarzenberg, SJ, Werlin, S, Wilschanski, M, Zimmerman, MB & Uc, A 2017, 'Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis', Pancreas, vol. 46, no. 6, pp. 764-769. https://doi.org/10.1097/MPA.0000000000000848
Troendle, David M. ; Fishman, Douglas S. ; Barth, Bradley A. ; Giefer, Matthew J. ; Lin, Tom K. ; Liu, Quin Y. ; Abu-El-Haija, Maisam ; Bellin, Melena D. ; Durie, Peter R. ; Freedman, Steven D. ; Gariepy, Cheryl ; Gonska, Tanja ; Heyman, Melvin B. ; Himes, Ryan ; Husain, Sohail Z. ; Kumar, Soma ; Lowe, Mark E. ; Morinville, Veronique D. ; Ooi, Chee Y. ; Palermo, Joseph ; Pohl, John F. ; Schwarzenberg, Sarah Jane ; Werlin, Steven ; Wilschanski, Michael ; Zimmerman, M. Bridget ; Uc, Aliye. / Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis. In: Pancreas. 2017 ; Vol. 46, No. 6. pp. 764-769.
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abstract = "Objective: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). Methods: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods. Results: One hundred seventeen children (38.9{\%}) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8{\%} vs 13.5{\%}, P > 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53{\%} vs 56{\%}, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5{\%}]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP. Conclusions: Therapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.",
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AU - Troendle, David M.

AU - Fishman, Douglas S.

AU - Barth, Bradley A.

AU - Giefer, Matthew J.

AU - Lin, Tom K.

AU - Liu, Quin Y.

AU - Abu-El-Haija, Maisam

AU - Bellin, Melena D.

AU - Durie, Peter R.

AU - Freedman, Steven D.

AU - Gariepy, Cheryl

AU - Gonska, Tanja

AU - Heyman, Melvin B.

AU - Himes, Ryan

AU - Husain, Sohail Z.

AU - Kumar, Soma

AU - Lowe, Mark E.

AU - Morinville, Veronique D.

AU - Ooi, Chee Y.

AU - Palermo, Joseph

AU - Pohl, John F.

AU - Schwarzenberg, Sarah Jane

AU - Werlin, Steven

AU - Wilschanski, Michael

AU - Zimmerman, M. Bridget

AU - Uc, Aliye

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KW - Bile stent

KW - Children

KW - Endotherapy

KW - Pancreatic ducts

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