Abstract
Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis. In order to control such oxidative stress, the importance of nuclear factor erythropoietin 2 related factor 2 (NRF2) has recently been highlighted. In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Additionally, we will discuss their effects on cardiac fibrosis via NRF2 activation.
| Original language | English (US) |
|---|---|
| Article number | 1259 |
| Pages (from-to) | 1-27 |
| Number of pages | 27 |
| Journal | Antioxidants |
| Volume | 9 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2020 |
Bibliographical note
Publisher Copyright:© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
- Cardiac fibrosis
- Lipoxins
- Maresins
- NRF2
- Neuroprotectins
- Resolvins
