Therapeutic effects of specialized pro-resolving lipids mediators on cardiac fibrosis via nrf2 activation

Gyeoung Jin Kang, Eun Ji Kim, Chang Hoon Lee

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis. In order to control such oxidative stress, the importance of nuclear factor erythropoietin 2 related factor 2 (NRF2) has recently been highlighted. In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Additionally, we will discuss their effects on cardiac fibrosis via NRF2 activation.

Original languageEnglish (US)
Article number1259
Pages (from-to)1-27
Number of pages27
JournalAntioxidants
Volume9
Issue number12
DOIs
StatePublished - Dec 2020

Bibliographical note

Funding Information:
This study was supported by grants from the Basic Science Research Program, through the NRF (NRF-2018R1E1A2A02057995, NRF-2018R1A5A2023127, NRF-2020R1A2C 3004973, and NRF-2020M3E5E2038356) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Korea (HP20C0131).

Funding Information:
Funding: This study was supported by grants from the Basic Science Research Program, through the NRF (NRF-2018R1E1A2A02057995, NRF-2018R1A5A2023127, NRF-2020R1A2C 3004973, and NRF-2020M3E5E2038356) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Korea (HP20C0131).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Cardiac fibrosis
  • Lipoxins
  • Maresins
  • NRF2
  • Neuroprotectins
  • Resolvins

PubMed: MeSH publication types

  • Journal Article
  • Review

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