Therapeutic algorithm for treatment of cytomegalovirus retinitis in persons with aids: A roundtable Summary

Henry H. Balfour, W. Lawrence Drew, W. David Hardy, M. H. Heinemann, Bruce Polsky

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Summary: Foscarnet and ganciclovir appear to be of similar effectiveness in halting active infection when given as induction therapy and in forestalling progression of disease when given as maintenance therapy in persons with AIDS who have cytomegalovirus (CMV) retinitis. The primary dose-limiting toxicity of foscarnet is nephrotoxicity, whereas that of ganciclovir is neutropenia. The availability of two effective agents with different toxicities permits selection of initial treatment for CMV retinitis based on individual patient characteristics and provides an alternative for therapy if drug intolerance or viral resistance develops. An approach to treatment of first-episode and recurrent CMV retinitis based on patient and drug characteristics is presented. Case reports detailing the use of foscarnet and ganciclovir and problems encountered in patient management are discussed.

Original languageEnglish (US)
Pages (from-to)S37-S44
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
StatePublished - Jan 1 1992

Keywords

  • AIDS
  • CMV retinitis
  • Drug intolerance
  • Foscarnet
  • Ganciclovir
  • Ganciclovir resistance
  • Induction therapy
  • Maintenance therapy

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