Therapeutic advantage of recombinant human plasminogen activator in endocarditis

Evidence from experiments in rabbits

M. W. Meyer, A. R. Witt, L. K. Krishnan, M. Yokota, M. J. Roszkowski, J. D. Rudney, M. C. Herzberg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In infective endocarditis vegetations are stabilized by fibrin. To learn if fibrin digestion would be therapeutic, experimental endocarditis was induced in rabbits by inoculation with a platelet-aggregating strain (Agg+) of Streptococcus sanguis and treated with recombinant tissue plasminogen activator (rt-PA), α-PA with penicillin, or penicillin alone. Control rabbits were inoculated with saline. All treatments of Agg+ endocarditis reduced the mass of valvular vegetations and clinical signs of endocarditis, including the frequency of left axis deviation and heart ischemia. rt-PA with penicillin was more effective than penicillin or rt-PA alone, reducing the mass of vegetations and clinical signs to that of saline controls. Within 50 min, rt-PA cleared 5-fold more 111Indium-labelled platelets from the heart than untreated rabbits and 1.4-fold more after 3 days. Combined with penicillin, thrombolytic therapy for human endocarditis should be reconsidered.

Original languageEnglish (US)
Pages (from-to)680-682
Number of pages3
JournalThrombosis and Haemostasis
Volume73
Issue number4
StatePublished - May 4 1995

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Plasminogen Activators
Endocarditis
Penicillins
Tissue Plasminogen Activator
Rabbits
Fibrin
Blood Platelets
Streptococcus sanguis
Therapeutics
Thrombolytic Therapy
Digestion
Ischemia

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Therapeutic advantage of recombinant human plasminogen activator in endocarditis : Evidence from experiments in rabbits. / Meyer, M. W.; Witt, A. R.; Krishnan, L. K.; Yokota, M.; Roszkowski, M. J.; Rudney, J. D.; Herzberg, M. C.

In: Thrombosis and Haemostasis, Vol. 73, No. 4, 04.05.1995, p. 680-682.

Research output: Contribution to journalArticle

Meyer, M. W. ; Witt, A. R. ; Krishnan, L. K. ; Yokota, M. ; Roszkowski, M. J. ; Rudney, J. D. ; Herzberg, M. C. / Therapeutic advantage of recombinant human plasminogen activator in endocarditis : Evidence from experiments in rabbits. In: Thrombosis and Haemostasis. 1995 ; Vol. 73, No. 4. pp. 680-682.
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