Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles

Nathan I. Walton, Zhe Gao, Ilya Zharov

Research output: Contribution to journalArticlepeer-review

Abstract

We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

Original languageEnglish (US)
JournalAnimal
Volume1625
Issue number1
DOIs
StatePublished - Jan 7 2014

Keywords

  • biomedical
  • nanostructure
  • sol-gel

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