Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles

Nathan I. Walton; Zhe Gao; Ilya Zharov

doi:10.1557/opl.2014.215

Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles

Nathan I. Walton, Zhe Gao, Ilya Zharov

Mechanical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

Original language	English (US)
Journal	Materials Research Society Symposium Proceedings
Volume	1625
DOIs	https://doi.org/10.1557/opl.2014.215
State	Published - 2014
Event	2013 MRS Fall Meeting - Boston, MA, United States Duration: Dec 1 2013 → Dec 6 2013

Keywords

biomedical
nanostructure
sol-gel

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1557/opl.2014.215

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title = "Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles",

abstract = "We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.",

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author = "Walton, {Nathan I.} and Zhe Gao and Ilya Zharov",

year = "2014",

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AU - Walton, Nathan I.

AU - Gao, Zhe

AU - Zharov, Ilya

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Y1 - 2014

N2 - We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

AB - We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

KW - biomedical

KW - nanostructure

KW - sol-gel

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U2 - 10.1557/opl.2014.215

DO - 10.1557/opl.2014.215

M3 - Conference article

AN - SCOPUS:84897986572

SN - 0272-9172

VL - 1625

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - 2013 MRS Fall Meeting

Y2 - 1 December 2013 through 6 December 2013

ER -

Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles

Abstract

Keywords

UN SDGs

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