Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles

Nathan I. Walton, Zhe Gao, Ilya Zharov

Research output: Contribution to journalConference article

Abstract

We prepared organically modified silica (ORMOSIL) nanoparticles with internal functional groups and mesoporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using gadolinium-157 nuclei. These modalities were incorporated by preparing ORMOSIL nanoparticles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating moieties inside the nanoparticles.

Original languageEnglish (US)
JournalMaterials Research Society Symposium Proceedings
Volume1625
DOIs
StatePublished - Jan 1 2014
Event2013 MRS Fall Meeting - Boston, MA, United States
Duration: Dec 1 2013Dec 6 2013

Fingerprint

Silicon Dioxide
Antineoplastic Agents
Silica
Nanoparticles
silicon dioxide
nanoparticles
Functional groups
Oncology
Gadolinium
gadolinium
Chelation
Magnetic resonance imaging
therapy
Neutrons
cancer
Metals
Imaging techniques
neutrons
nuclei
metals

Keywords

  • biomedical
  • nanostructure
  • sol-gel

Cite this

Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles. / Walton, Nathan I.; Gao, Zhe; Zharov, Ilya.

In: Materials Research Society Symposium Proceedings, Vol. 1625, 01.01.2014.

Research output: Contribution to journalConference article

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