Abstract
Abstract Sonoporation is a promising technology for promoting the transfer of drug or gene into cells using ultrasound-mediated microbubbles that transiently break up the cell membrane. In this article, a model is established to analyze the dynamics of ultrasound-mediated microbubble near the cell membrane, which may be especially useful for understanding the mechanisms of sonoporation. In the model, the velocity potential of fluid on the microbubble surface and on the cell membrane is obtained by the unsteady Bernoulli equations, and it is solved by using the boundary integral equations. By numerically analyzing the model, the typical microbubble dynamics near the cell membrane are enumerated, which may be mainly governed by mechanical index. The model also established the connections among the parameters of ultrasound exposure, microbubble characteristics, and cell membrane properties in sonoporation.
| Original language | English (US) |
|---|---|
| Article number | 5036 |
| Pages (from-to) | 136-144 |
| Number of pages | 9 |
| Journal | Ultrasonics |
| Volume | 61 |
| DOIs | |
| State | Published - Aug 1 2015 |
Bibliographical note
Funding Information:The Project was supported by National Natural Science Foundation of China (Grant No. 11404222 ); Science and Technology Planning Project of Shenzhen, China (Grant No. JCYJ20120828091734059, and GJHS20120621153609166 ); and Open Project from National–Regional Key Technology Engineering Laboratory for Medical Ultrasound, China.
Publisher Copyright:
© 2015 Elsevier B.V.
Keywords
- Boundary element method
- Cell membrane
- Microbubble
- Numerical model
- Sonoporation