Theoretical study of microbubble dynamics in sonoporation

Hao Yu, Zhongshi Lin, Liang Xu, Dalong Liu, Yuanyuan Shen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Abstract Sonoporation is a promising technology for promoting the transfer of drug or gene into cells using ultrasound-mediated microbubbles that transiently break up the cell membrane. In this article, a model is established to analyze the dynamics of ultrasound-mediated microbubble near the cell membrane, which may be especially useful for understanding the mechanisms of sonoporation. In the model, the velocity potential of fluid on the microbubble surface and on the cell membrane is obtained by the unsteady Bernoulli equations, and it is solved by using the boundary integral equations. By numerically analyzing the model, the typical microbubble dynamics near the cell membrane are enumerated, which may be mainly governed by mechanical index. The model also established the connections among the parameters of ultrasound exposure, microbubble characteristics, and cell membrane properties in sonoporation.

Original languageEnglish (US)
Article number5036
Pages (from-to)136-144
Number of pages9
JournalUltrasonics
Volume61
DOIs
StatePublished - Aug 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

  • Boundary element method
  • Cell membrane
  • Microbubble
  • Numerical model
  • Sonoporation

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