Theoretical Chemistry Answers Bimolecular Signaling Debate in [4Fe4S] Proteins

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Abstract

In this issue of Chem, Migliore and co-workers performed a theoretical study on redox signaling between the [4Fe4S] clusters in the C-terminal domain of DNA primase and polymerase α. They found that redox signaling cannot be accomplished solely via DNA-mediated charge transport, which requires [4Fe4S]-to-DNA and DNA-to-[4Fe4S] charge transfer.

Original languageEnglish (US)
Pages (from-to)12-14
Number of pages3
JournalChem
Volume5
Issue number1
DOIs
StatePublished - Jan 10 2019

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