Theoretical Background of Occupational-Exposure Models—Report of an Expert Workshop of the ISES Europe Working Group “Exposure Models”

Urs Schlüter, Susan Arnold, Francesca Borghi, John Cherrie, Wouter Fransman, Henri Heussen, Michael Jayjock, Keld Alstrup Jensen, Joonas Koivisto, Dorothea Koppisch, Jessica Meyer, Andrea Spinazzè, Celia Tanarro, Steven Verpaele, Natalie von Goetz

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On 20 October 2020, the Working Group “Exposure Models” of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) organised an online workshop to discuss the theoretical background of models for the assessment of occupational exposure to chemicals. In this report, participants of the workshop with an active role before and during the workshop summarise the most relevant discussion points and conclusions of this well-attended workshop. ISES Europe has identified exposure modelling as one priority area for the strategic development of exposure science in Europe in the coming years. This specific workshop aimed to discuss the main challenges in developing, validating, and using occupational-exposure models for regulatory purposes. The theoretical background, application domain, and limitations of different modelling approaches were presented and discussed, focusing on empirical “modifying-factor” or “mass-balance-based” approaches. During the discussions, these approaches were compared and analysed. Possibilities to address the discussed challenges could be a validation study involving alternative modelling approaches. The wider discussion touched upon the close relationship between modelling and monitoring and the need for better linkage of the methods and the need for common monitoring databases that include data on model parameters.

Original languageEnglish (US)
Article number1234
JournalInternational journal of environmental research and public health
Issue number3
StatePublished - Feb 1 2022

Bibliographical note

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • Mass-balance model
  • Modifying-factor model
  • Occupational-exposure modelling
  • Regulatory exposure modelling
  • Workshop


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