The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: Where time and place matter Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn

Ad P. Koets; Shigetoshi Eda; Srinand Sreevatsan

doi:10.1186/s13567-015-0185-0

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: Where time and place matter Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn

Ad P. Koets, Shigetoshi Eda, Srinand Sreevatsan

Veterinary Population Medicine

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

Johne's disease or paratuberculosis, caused by Mycobacterium avium subsp. Paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of bovine Johne's disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics including the temporal and the spatial context relevant for the various host-pathogen interactions.

Original language	English (US)
Article number	61
Journal	Veterinary research
Volume	46
Issue number	1
DOIs	https://doi.org/10.1186/s13567-015-0185-0
State	Published - Jun 19 2015

Bibliographical note

Funding Information:
The authors thank Judy Stabel and Eiichi Momotani for critical reading of the manuscript. The authors acknowledge the support of the Within-host modeling of MAP infections Working Group at the National Institute for Mathematical and Biological Synthesis, sponsored by the National Science Foundation, the U.S. Department of Homeland Security, and the U.S. Department of Agriculture through NSF Award DBI-1300426, with additional support from The University of Tennessee, Knoxville.

Publisher Copyright:
© 2015 Koets et al. 11. References:.

Publisher link

10.1186/s13567-015-0185-0

Find It

Find It at U of M Libraries

Cite this

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle : Where time and place matter Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn. / Koets, Ad P.; Eda, Shigetoshi; Sreevatsan, Srinand.

In: Veterinary research, Vol. 46, No. 1, 61, 19.06.2015.

Research output: Contribution to journal › Review article › peer-review

@article{b7e696d7f5854bd1938c555f201dd266,

title = "The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: Where time and place matter Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn",

abstract = "Johne's disease or paratuberculosis, caused by Mycobacterium avium subsp. Paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of bovine Johne's disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics including the temporal and the spatial context relevant for the various host-pathogen interactions.",

author = "Koets, {Ad P.} and Shigetoshi Eda and Srinand Sreevatsan",

note = "Funding Information: The authors thank Judy Stabel and Eiichi Momotani for critical reading of the manuscript. The authors acknowledge the support of the Within-host modeling of MAP infections Working Group at the National Institute for Mathematical and Biological Synthesis, sponsored by the National Science Foundation, the U.S. Department of Homeland Security, and the U.S. Department of Agriculture through NSF Award DBI-1300426, with additional support from The University of Tennessee, Knoxville. Publisher Copyright: {\textcopyright} 2015 Koets et al. 11. References:.",

year = "2015",

month = jun,

day = "19",

doi = "10.1186/s13567-015-0185-0",

language = "English (US)",

volume = "46",

journal = "Annales de Recherches Veterinaires",

issn = "0928-4249",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle

T2 - Where time and place matter Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn

AU - Koets, Ad P.

AU - Eda, Shigetoshi

AU - Sreevatsan, Srinand

N1 - Funding Information: The authors thank Judy Stabel and Eiichi Momotani for critical reading of the manuscript. The authors acknowledge the support of the Within-host modeling of MAP infections Working Group at the National Institute for Mathematical and Biological Synthesis, sponsored by the National Science Foundation, the U.S. Department of Homeland Security, and the U.S. Department of Agriculture through NSF Award DBI-1300426, with additional support from The University of Tennessee, Knoxville. Publisher Copyright: © 2015 Koets et al. 11. References:.

PY - 2015/6/19

Y1 - 2015/6/19

N2 - Johne's disease or paratuberculosis, caused by Mycobacterium avium subsp. Paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of bovine Johne's disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics including the temporal and the spatial context relevant for the various host-pathogen interactions.

AB - Johne's disease or paratuberculosis, caused by Mycobacterium avium subsp. Paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of bovine Johne's disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics including the temporal and the spatial context relevant for the various host-pathogen interactions.

UR - http://www.scopus.com/inward/record.url?scp=84931022699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931022699&partnerID=8YFLogxK

U2 - 10.1186/s13567-015-0185-0

DO - 10.1186/s13567-015-0185-0

M3 - Review article

C2 - 26092382

AN - SCOPUS:84931022699

VL - 46

JO - Annales de Recherches Veterinaires

JF - Annales de Recherches Veterinaires

SN - 0928-4249

IS - 1

M1 - 61

ER -

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: Where time and place matter Modeling Johne's disease: From the inside out Dr Ad Koets and Prof Yrjo Grohn

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this