The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase

Guotai Yu; Oadi Matny; Spyridon Gourdoupis; Naganand Rayapuram; Fatimah R. Aljedaani; Yan L. Wang; Thorsten Nürnberger; Ryan Johnson; Emma E. Crean; Isabel M.L. Saur; Catherine Gardener; Yajuan Yue; Ngonidzashe Kangara; Burkhard Steuernagel; Sadiye Hayta; Mark Smedley; Wendy Harwood; Mehran Patpour; Shuangye Wu; Jesse Poland; Jonathan D.G. Jones; T. Lynne Reuber; Moshe Ronen; Amir Sharon; Matthew N. Rouse; Steven Xu; Kateřina Holušová; Jan Bartoš; István Molnár; Miroslava Karafiátová; Heribert Hirt; Ikram Blilou; Łukasz Jaremko; Jaroslav Doležel; Brian J. Steffenson; Brande B.H. Wulff

doi:10.1038/s41588-023-01402-1

The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase

Guotai Yu, Oadi Matny, Spyridon Gourdoupis, Naganand Rayapuram, Fatimah R. Aljedaani, Yan L. Wang, Thorsten Nürnberger, Ryan Johnson, Emma E. Crean, Isabel M.L. Saur, Catherine Gardener, Yajuan Yue, Ngonidzashe Kangara, Burkhard Steuernagel, Sadiye Hayta, Mark Smedley, Wendy Harwood, Mehran Patpour, Shuangye Wu, Jesse PolandJonathan D.G. Jones, T. Lynne Reuber, Moshe Ronen, Amir Sharon, Matthew N. Rouse, Steven Xu, Kateřina Holušová, Jan Bartoš, István Molnár, Miroslava Karafiátová, Heribert Hirt, Ikram Blilou, Łukasz Jaremko, Jaroslav Doležel, Brian J. Steffenson, Brande B.H. Wulff

Plant Pathology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool¹. Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum ^2,3. Sr43 encodes an active protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering.

Original language	English (US)
Pages (from-to)	921-926
Number of pages	6
Journal	Nature Genetics
Volume	55
Issue number	6
DOIs	https://doi.org/10.1038/s41588-023-01402-1
State	Published - Jun 2023

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© 2023, The Author(s).

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Yu, G., Matny, O., Gourdoupis, S., Rayapuram, N., Aljedaani, F. R., Wang, Y. L., Nürnberger, T., Johnson, R., Crean, E. E., Saur, I. M. L., Gardener, C., Yue, Y., Kangara, N., Steuernagel, B., Hayta, S., Smedley, M., Harwood, W., Patpour, M., Wu, S., ... Wulff, B. B. H. (2023). The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase. Nature Genetics, 55(6), 921-926. https://doi.org/10.1038/s41588-023-01402-1

Yu, G, Matny, O, Gourdoupis, S, Rayapuram, N, Aljedaani, FR, Wang, YL, Nürnberger, T, Johnson, R, Crean, EE, Saur, IML, Gardener, C, Yue, Y, Kangara, N, Steuernagel, B, Hayta, S, Smedley, M, Harwood, W, Patpour, M, Wu, S, Poland, J, Jones, JDG, Reuber, TL, Ronen, M, Sharon, A, Rouse, MN, Xu, S, Holušová, K, Bartoš, J, Molnár, I, Karafiátová, M, Hirt, H, Blilou, I, Jaremko, Ł, Doležel, J, Steffenson, BJ & Wulff, BBH 2023, 'The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase', Nature Genetics, vol. 55, no. 6, pp. 921-926. https://doi.org/10.1038/s41588-023-01402-1

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abstract = "To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool1. Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum 2,3. Sr43 encodes an active protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering.",

author = "Guotai Yu and Oadi Matny and Spyridon Gourdoupis and Naganand Rayapuram and Aljedaani, {Fatimah R.} and Wang, {Yan L.} and Thorsten N{\"u}rnberger and Ryan Johnson and Crean, {Emma E.} and Saur, {Isabel M.L.} and Catherine Gardener and Yajuan Yue and Ngonidzashe Kangara and Burkhard Steuernagel and Sadiye Hayta and Mark Smedley and Wendy Harwood and Mehran Patpour and Shuangye Wu and Jesse Poland and Jones, {Jonathan D.G.} and Reuber, {T. Lynne} and Moshe Ronen and Amir Sharon and Rouse, {Matthew N.} and Steven Xu and Kate{\v r}ina Holu{\v s}ov{\'a} and Jan Barto{\v s} and Istv{\'a}n Moln{\'a}r and Miroslava Karafi{\'a}tov{\'a} and Heribert Hirt and Ikram Blilou and {\L}ukasz Jaremko and Jaroslav Dole{\v z}el and Steffenson, {Brian J.} and Wulff, {Brande B.H.}",

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AU - Matny, Oadi

AU - Gourdoupis, Spyridon

AU - Rayapuram, Naganand

AU - Aljedaani, Fatimah R.

AU - Wang, Yan L.

AU - Nürnberger, Thorsten

AU - Johnson, Ryan

AU - Crean, Emma E.

AU - Saur, Isabel M.L.

AU - Gardener, Catherine

AU - Yue, Yajuan

AU - Kangara, Ngonidzashe

AU - Steuernagel, Burkhard

AU - Hayta, Sadiye

AU - Smedley, Mark

AU - Harwood, Wendy

AU - Patpour, Mehran

AU - Wu, Shuangye

AU - Poland, Jesse

AU - Jones, Jonathan D.G.

AU - Reuber, T. Lynne

AU - Ronen, Moshe

AU - Sharon, Amir

AU - Rouse, Matthew N.

AU - Xu, Steven

AU - Holušová, Kateřina

AU - Bartoš, Jan

AU - Molnár, István

AU - Karafiátová, Miroslava

AU - Hirt, Heribert

AU - Blilou, Ikram

AU - Jaremko, Łukasz

AU - Doležel, Jaroslav

AU - Steffenson, Brian J.

AU - Wulff, Brande B.H.

PY - 2023/6

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N2 - To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool1. Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum 2,3. Sr43 encodes an active protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering.

AB - To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool1. Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum 2,3. Sr43 encodes an active protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering.

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The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase

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