The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus

Rohit Mago; Peng Zhang; Sonia Vautrin; Hana Šimková; Urmil Bansal; Ming Cheng Luo; Matthew Rouse; Haydar Karaoglu; Sambasivam Periyannan; James Kolmer; Yue Jin; Michael A. Ayliffe; Harbans Bariana; Robert F. Park; Robert McIntosh; Jaroslav Doležel; Hélène Bergès; Wolfgang Spielmeyer; Evans S. Lagudah; Jeff G. Ellis; Peter N. Dodds

doi:10.1038/nplants.2015.186

The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus

Rohit Mago, Peng Zhang, Sonia Vautrin, Hana Šimková, Urmil Bansal, Ming Cheng Luo, Matthew Rouse, Haydar Karaoglu, Sambasivam Periyannan, James Kolmer, Yue Jin, Michael A. Ayliffe, Harbans Bariana, Robert F. Park, Robert McIntosh, Jaroslav Doležel, Hélène Bergès, Wolfgang Spielmeyer, Evans S. Lagudah, Jeff G. EllisPeter N. Dodds

Plant Pathology

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

We identify the wheat stem rust resistance gene Sr50 (using physical mapping, mutation and complementation) as homologous to barley Mla, encoding a coiled-coil nucleotide-binding leucine-rich repeat (CC-NB-LRR) protein. We show that Sr50 confers a unique resistance specificity different from Sr31 and other genes on rye chromosome 1RS, and is effective against the broadly virulent Ug99 race lineage. Extensive haplotype diversity at the rye Sr50 locus holds promise for mining effective resistance genes.

Original language	English (US)
Article number	15186
Journal	Nature plants
Volume	1
DOIs	https://doi.org/10.1038/nplants.2015.186
State	Published - Nov 30 2015

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Mago, R., Zhang, P., Vautrin, S., Šimková, H., Bansal, U., Luo, M. C., Rouse, M., Karaoglu, H., Periyannan, S., Kolmer, J., Jin, Y., Ayliffe, M. A., Bariana, H., Park, R. F., McIntosh, R., Doležel, J., Bergès, H., Spielmeyer, W., Lagudah, E. S., ... Dodds, P. N. (2015). The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus. Nature plants, 1, Article 15186. https://doi.org/10.1038/nplants.2015.186

Mago, R, Zhang, P, Vautrin, S, Šimková, H, Bansal, U, Luo, MC, Rouse, M, Karaoglu, H, Periyannan, S, Kolmer, J , Jin, Y, Ayliffe, MA, Bariana, H, Park, RF, McIntosh, R, Doležel, J, Bergès, H, Spielmeyer, W, Lagudah, ES, Ellis, JG & Dodds, PN 2015, 'The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus', Nature plants, vol. 1, 15186. https://doi.org/10.1038/nplants.2015.186

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abstract = "We identify the wheat stem rust resistance gene Sr50 (using physical mapping, mutation and complementation) as homologous to barley Mla, encoding a coiled-coil nucleotide-binding leucine-rich repeat (CC-NB-LRR) protein. We show that Sr50 confers a unique resistance specificity different from Sr31 and other genes on rye chromosome 1RS, and is effective against the broadly virulent Ug99 race lineage. Extensive haplotype diversity at the rye Sr50 locus holds promise for mining effective resistance genes.",

author = "Rohit Mago and Peng Zhang and Sonia Vautrin and Hana {\v S}imkov{\'a} and Urmil Bansal and Luo, {Ming Cheng} and Matthew Rouse and Haydar Karaoglu and Sambasivam Periyannan and James Kolmer and Yue Jin and Ayliffe, {Michael A.} and Harbans Bariana and Park, {Robert F.} and Robert McIntosh and Jaroslav Dole{\v z}el and H{\'e}l{\`e}ne Berg{\`e}s and Wolfgang Spielmeyer and Lagudah, {Evans S.} and Ellis, {Jeff G.} and Dodds, {Peter N.}",

year = "2015",

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doi = "10.1038/nplants.2015.186",

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AU - Mago, Rohit

AU - Zhang, Peng

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AU - Šimková, Hana

AU - Bansal, Urmil

AU - Luo, Ming Cheng

AU - Rouse, Matthew

AU - Karaoglu, Haydar

AU - Periyannan, Sambasivam

AU - Kolmer, James

AU - Jin, Yue

AU - Ayliffe, Michael A.

AU - Bariana, Harbans

AU - Park, Robert F.

AU - McIntosh, Robert

AU - Doležel, Jaroslav

AU - Bergès, Hélène

AU - Spielmeyer, Wolfgang

AU - Lagudah, Evans S.

AU - Ellis, Jeff G.

AU - Dodds, Peter N.

PY - 2015/11/30

Y1 - 2015/11/30

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AB - We identify the wheat stem rust resistance gene Sr50 (using physical mapping, mutation and complementation) as homologous to barley Mla, encoding a coiled-coil nucleotide-binding leucine-rich repeat (CC-NB-LRR) protein. We show that Sr50 confers a unique resistance specificity different from Sr31 and other genes on rye chromosome 1RS, and is effective against the broadly virulent Ug99 race lineage. Extensive haplotype diversity at the rye Sr50 locus holds promise for mining effective resistance genes.

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The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus

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