The nuclear receptor is an emerging therapeutic target in various human diseases. Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D. Classically, vitamin D is recognized as an essential contributor to mineral and bone homeostasis. Increasing evidence demonstrates that vitamin D is involved in inflammatory responses. Persistent intestinal inflammation is associated with colon cancer. This review focuses on vitamin D and VDR in inflammatory bowel diseases and colon cancer. We place emphasis on the regulatory roles of vitamin D/VDR in inflammation, enteric bacteria, and tumorigenesis. We summarize the signaling pathways regulated by VDR in intestinal homeosta-sis. Finally, we discuss the potential application of the insights gleaned from these findings to personalized therapies in chronic inflammation and colon cancer.
|Original language||English (US)|
|Number of pages||9|
|Journal||Current Colorectal Cancer Reports|
|State||Published - Mar 2012|
Bibliographical noteFunding Information:
This work was supported by the National Institutes of Health (DK075386-0251, R03DK089010-01), the American Cancer Society (RSG-09-075-01-MBC), and the IDEAL award from Empire State Stem Cell Board (N09G-279) to Jun Sun.
- Colon cancer
- Enteric bacteria
- Gut flora
- Molecular epidemiology
- Nuclear receptor
- Vitamin D
- Vitamin D receptor