TY - JOUR
T1 - The virtual aging brain
T2 - Causal inference supports interhemispheric dedifferentiation in healthy aging
AU - Lavanga, Mario
AU - Stumme, Johanna
AU - Yalcinkaya, Bahar Hazal
AU - Fousek, Jan
AU - Jockwitz, Christiane
AU - Sheheitli, Hiba
AU - Bittner, Nora
AU - Hashemi, Meysam
AU - Petkoski, Spase
AU - Caspers, Svenja
AU - Jirsa, Viktor
N1 - Publisher Copyright:
© 2023
PY - 2023/12/1
Y1 - 2023/12/1
N2 - The mechanisms of cognitive decline and its variability during healthy aging are not fully understood, but have been associated with reorganization of white matter tracts and functional brain networks. Here, we built a brain network modeling framework to infer the causal link between structural connectivity and functional architecture and the consequent cognitive decline in aging. By applying in-silico interhemispheric degradation of structural connectivity, we reproduced the process of functional dedifferentiation during aging. Thereby, we found the global modulation of brain dynamics by structural connectivity to increase with age, which was steeper in older adults with poor cognitive performance. We validated our causal hypothesis via a deep-learning Bayesian approach. Our results might be the first mechanistic demonstration of dedifferentiation during aging leading to cognitive decline.
AB - The mechanisms of cognitive decline and its variability during healthy aging are not fully understood, but have been associated with reorganization of white matter tracts and functional brain networks. Here, we built a brain network modeling framework to infer the causal link between structural connectivity and functional architecture and the consequent cognitive decline in aging. By applying in-silico interhemispheric degradation of structural connectivity, we reproduced the process of functional dedifferentiation during aging. Thereby, we found the global modulation of brain dynamics by structural connectivity to increase with age, which was steeper in older adults with poor cognitive performance. We validated our causal hypothesis via a deep-learning Bayesian approach. Our results might be the first mechanistic demonstration of dedifferentiation during aging leading to cognitive decline.
KW - Aging
KW - Cognitive decline
KW - Functional connectivity
KW - Functional dedifferentiation
KW - Structural connectivity
KW - White-matter degradation
UR - http://www.scopus.com/inward/record.url?scp=85174906979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85174906979&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2023.120403
DO - 10.1016/j.neuroimage.2023.120403
M3 - Article
C2 - 37865260
AN - SCOPUS:85174906979
SN - 1053-8119
VL - 283
JO - NeuroImage
JF - NeuroImage
M1 - 120403
ER -