The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection

Martin Markowitz, Florin Vaida, C. Bradley Hare, Daniel Boden, Hiroshi Mohri, Frederick M. Hecht, Robert C. Kalayjian, Ann Conrad, Donna Mildvan, Judith Aberg, Christine Hogan, J. Michael Kilby, Henry H. Balfour, Kim Schafer, Douglas Richman, Susan Little

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Abstract

Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4+ T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologie or immunologic benefit.

Original languageEnglish (US)
Pages (from-to)1298-1302
Number of pages5
JournalJournal of Infectious Diseases
Volume201
Issue number9
DOIs
StatePublished - May 1 2010

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    Markowitz, M., Vaida, F., Bradley Hare, C., Boden, D., Mohri, H., Hecht, F. M., Kalayjian, R. C., Conrad, A., Mildvan, D., Aberg, J., Hogan, C., Michael Kilby, J., Balfour, H. H., Schafer, K., Richman, D., & Little, S. (2010). The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection. Journal of Infectious Diseases, 201(9), 1298-1302. https://doi.org/10.1086/651664