The variance of phase-resetting curves

G. Bard Ermentrout, Bryce Beverlin, Todd Troyer, Theoden I. Netoff

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Phase resetting curves (PRCs) provide a measure of the sensitivity of oscillators to perturbations. In a noisy environment, these curves are themselves very noisy. Using perturbation theory, we compute the mean and the variance for PRCs for arbitrary limit cycle oscillators when the noise is small. Phase resetting curves and phase dependent variance are fit to experimental data and the variance is computed using an ad-hoc method. The theoretical curves of this phase dependent method match both simulations and experimental data significantly better than an ad-hoc method. A dual cell network simulation is compared to predictions using the analytical phase dependent variance estimation presented in this paper. We also discuss how entrainment of a neuron to a periodic pulse depends on the noise amplitude.

Original languageEnglish (US)
Pages (from-to)185-197
Number of pages13
JournalJournal of Computational Neuroscience
Volume31
Issue number2
DOIs
StatePublished - Oct 1 2011

Keywords

  • Neural oscillators
  • Noise
  • Phase resetting
  • Synchrony
  • Variance

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