The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

Dean W. Ballard, William H. Walker, Stefan Doerre, Prakash Sista, Jerry A Molitor, Eric P. Dixon, Nancy J. Peffer, Mark Hannink, Warner C. Greene

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Abstract

Studies of NF-κB suggest that this enhancer binding activity corresponds to a family of at least four proteins (p50, p55, p75, and p85) differentially induced with biphasic kinetics during T cell activation. While p55 and p50 are closely related to the 50 kd DNA binding subunit of NF-κB, p75 and p85 exhibit DNA binding properties that distinguish them from this 50 kd poly-peptide and its regulatory subunits IκB and p65. All four members of this κB-specific protein family are structurally related to the v-Rel oncoprotein and one, p85, appears identical to human c-Rel. v-Rel, but not nontransforming v-Rel mutants, binds to the κB enhancer and inhibits NF-κB-activated transcription from the IL-2 receptor α promoter and HIV-1 LTR. These findings suggest a Rel-related family of κB enhancer binding proteins and raise the possibility that the transforming activity of v-Rel is Iinked to its inhibitory action on cellular genes under NF-κB control.

Original languageEnglish (US)
Pages (from-to)803-814
Number of pages12
JournalCell
Volume63
Issue number4
DOIs
StatePublished - Nov 16 1990
Externally publishedYes

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Ballard, D. W., Walker, W. H., Doerre, S., Sista, P., Molitor, J. A., Dixon, E. P., Peffer, N. J., Hannink, M., & Greene, W. C. (1990). The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Cell, 63(4), 803-814. https://doi.org/10.1016/0092-8674(90)90146-6