The Ussing chamber and measurement of drug actions on mucosal ion transport

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Abstract

Ussing chamber technology can be used to investigate the pharmacodynamic and pharmacokinetic properties of drugs and natural substances on polarized epithelia. With this approach, epithelial sheets or confluent epithelial cell monolayers are mounted between two half-chambers, permitting compound delivery to either the apical or basolateral cell surface. Described in this unit are protocols for determining the effects of test compounds on transepithelial ion transport processes.

Original languageEnglish (US)
Pages (from-to)7.12.1-7.12.17
JournalCurrent Protocols in Pharmacology
Issue numberSUPPL. 41
DOIs
StatePublished - Dec 15 2008

Keywords

  • Airways
  • Epithelial cell culture
  • Epithelium
  • Intestine
  • Pharmacokinetics
  • Skin
  • Transepithelial ion transport

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