The Use of Vitamin D Metabolites and Analogues in the Treatment of Chronic Kidney Disease

Ladan Zand, Rajiv Kumar

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are associated with abnormalities in bone and mineral metabolism, known as CKD-bone mineral disorder. CKD and ESRD cause skeletal abnormalities characterized by hyperparathyroidism, mixed uremic osteodystrophy, osteomalacia, adynamic bone disease, and frequently enhanced vascular and ectopic calcification. Hyperparathyroidism and mixed uremic osteodystrophy are the most common manifestations due to phosphate retention, reduced concentrations of 1,25-dihydroxyvitamin D, intestinal calcium absorption, and negative calcium balance. Treatment with 1-hydroxylated vitamin D analogues is useful.

Original languageEnglish (US)
Pages (from-to)983-1007
Number of pages25
JournalEndocrinology and Metabolism Clinics of North America
Volume46
Issue number4
DOIs
StatePublished - Dec 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

  • Chronic kidney disease
  • End-stage renal disease
  • Vitamin D analogues

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