The use of synthetic peptides in the study of experimental autoimmune uveitis

Larry A. Donoso, Dale S Gregerson, Steven P. Fling, Carmen F. Merryman, Theodore W. Sery

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

S-antigen is a highly pathogenic retinal autoantigen for the induction of experimental autoimmune uveitis (EAU). EAU is predominately a T cell mediated autoimmune disease of the uveal tract and retina of the eye and the pinealocytes of the pineal gland. Using synthetic peptides it has been possible to identify several B cell and T cell epitopes in the molecule. In addition, synthetic peptides derived from proteins of diverse origin with amino acid sequence homology to pathogenic regions of S-antigen induce an EAU which is indistinguishable from the disease induced by native S-antigen. These studies aid in the understanding of immune mechanisms in EAU and provide a basis for the pathogenesis of uveitis in humans.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalCurrent Eye Research
Volume9
Issue numberS1
DOIs
StatePublished - Jan 1 1990

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