The use of magnetic resonance spectroscopy as a tool for the measurement of bi-hemispheric transcranial electric stimulation effects on primary motor cortex metabolism

Sara Tremblay, Vincent Beaulé, Sébastien Proulx, Louis Philippe Lafleur, Julien Doyon, Małgorzata Marjańska, Hugo Théoret

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Transcranial direct current stimulation (tDCS) is a neuromodulation technique that has been increasingly used over the past decade in the treatment of neurological and psychiatric disorders such as stroke and depression. Yet, the mechanisms underlying its ability to modulate brain excitability to improve clinical symptoms remains poorly understood 33. To help improve this understanding, proton magnetic resonance spectroscopy (1H-MRS) can be used as it allows the in vivo quantification of brain metabolites such as γ-aminobutyric acid (GABA) and glutamate in a region-specific manner 41. In fact, a recent study demonstrated that 1H-MRS is indeed a powerful means to better understand the effects of tDCS on neurotransmitter concentration 34. This article aims to describe the complete protocol for combining tDCS (NeuroConn MR compatible stimulator) with 1H-MRS at 3 T using a MEGA-PRESS sequence. We will describe the impact of a protocol that has shown great promise for the treatment of motor dysfunctions after stroke, which consists of bilateral stimulation of primary motor cortices 27,30,31. Methodological factors to consider and possible modifications to the protocol are also discussed.

Original languageEnglish (US)
Article numbere51631
JournalJournal of Visualized Experiments
Issue number93
DOIs
StatePublished - Nov 19 2014

Bibliographical note

Publisher Copyright:
© 2014, Journal of Visualized Experiments. All rights reserved.

Keywords

  • GABA
  • Glutamate
  • Issue 93
  • Neuroscience
  • Primary motor cortex
  • Proton magnetic resonance spectroscopy
  • Stroke
  • Transcranial direct current stimulation

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