The ups and downs of p53: Understanding protein dynamics in single cells

Eric Batchelor, Alexander Loewer, Galit Lahav

Research output: Contribution to journalReview articlepeer-review

186 Scopus citations


Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

Original languageEnglish (US)
Pages (from-to)371-377
Number of pages7
JournalNature Reviews Cancer
Issue number5
StatePublished - May 2009
Externally publishedYes

Bibliographical note

Funding Information:
We thank all the members of our laboratory for useful discussions. This work was supported by National Institutes of Health Grant GM083303. E.B. was supported by the American Cancer Society, California Division, Pamela and Edward Taft Postdoctoral Fellowship.


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