Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
Bibliographical noteFunding Information:
We thank all the members of our laboratory for useful discussions. This work was supported by National Institutes of Health Grant GM083303. E.B. was supported by the American Cancer Society, California Division, Pamela and Edward Taft Postdoctoral Fellowship.