The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies

Hirotaka Tao, Yasuhiko Kawakami, Chi Chung Hui, Sevan Hopyan

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270. For further resources related to this article, please visit the WIREs website.

Original languageEnglish (US)
Article numbere270
JournalWiley Interdisciplinary Reviews: Developmental Biology
Volume6
Issue number4
DOIs
StatePublished - Jul 1 2017

Bibliographical note

Funding Information:
This work was supported by a CIHR grant to S.H. and C-c.H (137092) and an NIH grant to Y.K. (AR064195).

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