Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270. For further resources related to this article, please visit the WIREs website.
|Original language||English (US)|
|Journal||Wiley Interdisciplinary Reviews: Developmental Biology|
|State||Published - Jul 1 2017|
Bibliographical noteFunding Information:
This work was supported by a CIHR grant to S.H. and C-c.H (137092) and an NIH grant to Y.K. (AR064195).