The Trp64Arg polymorphism of the β3-adrenergic receptor is not increased in women with preeclampsia

Amanda N. Malina; Hannele M. Laivuori; Patricia K. Agatisa; Lynn A. Collura; William R. Crombleholme; Cynthia J. Sims; James M. Roberts

doi:10.1016/j.ajog.2003.09.026

The Trp64Arg polymorphism of the β₃-adrenergic receptor is not increased in women with preeclampsia

Amanda N. Malina, Hannele M. Laivuori, Patricia K. Agatisa, Lynn A. Collura, William R. Crombleholme, Cynthia J. Sims, James M. Roberts

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective: Insulin resistance is greater and obesity is more common in women with preeclampsia. The Trp64Arg polymorphism in the β₃- adrenergic receptor is associated with these metabolic changes. This study investigated whether the Trp64Arg polymorphism is more common in women with preeclampsia. Study design: β₃-Adrenergic receptor genotypes were determined in 177 women with a history of preeclampsia and in 179 normal pregnancies. We also compared prepregnancy body mass index (BMI), length of gestation, baby weight percentile, and glucose values during an oral tolerance test in women with and without the polymorphism. Results: The genotypes and allele frequency did not differ significantly between women with preeclamptic and normal pregnancies (P = .17). Women with and without the polymorphism had similar prepregnancy BMI, glucose at 1-hour screening, gestational age at delivery, and adjusted baby weight. Conclusion: The Trp64Arg polymorphism of the β₃-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.

Original language	English (US)
Pages (from-to)	779-783
Number of pages	5
Journal	American journal of obstetrics and gynecology
Volume	190
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2003.09.026
State	Published - Mar 2004
Externally published	Yes

Bibliographical note

Funding Information:
Supported by National Institutes of Health grants No. P01 HD30367 and P01 HD30367-09, Magee-Womens Hospital CRC grant No. 5M01 RR00056, and the Howard Hughes Medical Institute Research Fellowship Program for Medical Students.

Keywords

Metabolic syndrome
Polymorphism
Preeclampsia
βReceptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.ajog.2003.09.026

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title = "The Trp64Arg polymorphism of the β3-adrenergic receptor is not increased in women with preeclampsia",

abstract = "Objective: Insulin resistance is greater and obesity is more common in women with preeclampsia. The Trp64Arg polymorphism in the β3- adrenergic receptor is associated with these metabolic changes. This study investigated whether the Trp64Arg polymorphism is more common in women with preeclampsia. Study design: β3-Adrenergic receptor genotypes were determined in 177 women with a history of preeclampsia and in 179 normal pregnancies. We also compared prepregnancy body mass index (BMI), length of gestation, baby weight percentile, and glucose values during an oral tolerance test in women with and without the polymorphism. Results: The genotypes and allele frequency did not differ significantly between women with preeclamptic and normal pregnancies (P = .17). Women with and without the polymorphism had similar prepregnancy BMI, glucose at 1-hour screening, gestational age at delivery, and adjusted baby weight. Conclusion: The Trp64Arg polymorphism of the β3-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.",

keywords = "Metabolic syndrome, Polymorphism, Preeclampsia, βReceptor",

author = "Malina, \{Amanda N.\} and Laivuori, \{Hannele M.\} and Agatisa, \{Patricia K.\} and Collura, \{Lynn A.\} and Crombleholme, \{William R.\} and Sims, \{Cynthia J.\} and Roberts, \{James M.\}",

note = "Funding Information: Supported by National Institutes of Health grants No. P01 HD30367 and P01 HD30367-09, Magee-Womens Hospital CRC grant No. 5M01 RR00056, and the Howard Hughes Medical Institute Research Fellowship Program for Medical Students. ",

year = "2004",

month = mar,

doi = "10.1016/j.ajog.2003.09.026",

language = "English (US)",

volume = "190",

pages = "779--783",

journal = "American journal of obstetrics and gynecology",

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T1 - The Trp64Arg polymorphism of the β3-adrenergic receptor is not increased in women with preeclampsia

AU - Malina, Amanda N.

AU - Laivuori, Hannele M.

AU - Agatisa, Patricia K.

AU - Collura, Lynn A.

AU - Crombleholme, William R.

AU - Sims, Cynthia J.

AU - Roberts, James M.

N1 - Funding Information: Supported by National Institutes of Health grants No. P01 HD30367 and P01 HD30367-09, Magee-Womens Hospital CRC grant No. 5M01 RR00056, and the Howard Hughes Medical Institute Research Fellowship Program for Medical Students.

PY - 2004/3

Y1 - 2004/3

N2 - Objective: Insulin resistance is greater and obesity is more common in women with preeclampsia. The Trp64Arg polymorphism in the β3- adrenergic receptor is associated with these metabolic changes. This study investigated whether the Trp64Arg polymorphism is more common in women with preeclampsia. Study design: β3-Adrenergic receptor genotypes were determined in 177 women with a history of preeclampsia and in 179 normal pregnancies. We also compared prepregnancy body mass index (BMI), length of gestation, baby weight percentile, and glucose values during an oral tolerance test in women with and without the polymorphism. Results: The genotypes and allele frequency did not differ significantly between women with preeclamptic and normal pregnancies (P = .17). Women with and without the polymorphism had similar prepregnancy BMI, glucose at 1-hour screening, gestational age at delivery, and adjusted baby weight. Conclusion: The Trp64Arg polymorphism of the β3-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.

AB - Objective: Insulin resistance is greater and obesity is more common in women with preeclampsia. The Trp64Arg polymorphism in the β3- adrenergic receptor is associated with these metabolic changes. This study investigated whether the Trp64Arg polymorphism is more common in women with preeclampsia. Study design: β3-Adrenergic receptor genotypes were determined in 177 women with a history of preeclampsia and in 179 normal pregnancies. We also compared prepregnancy body mass index (BMI), length of gestation, baby weight percentile, and glucose values during an oral tolerance test in women with and without the polymorphism. Results: The genotypes and allele frequency did not differ significantly between women with preeclamptic and normal pregnancies (P = .17). Women with and without the polymorphism had similar prepregnancy BMI, glucose at 1-hour screening, gestational age at delivery, and adjusted baby weight. Conclusion: The Trp64Arg polymorphism of the β3-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.

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KW - βReceptor

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