The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Chaofan Li; Bibo Zhu; Young Min Son; Zheng Wang; Li Jiang; Min Xiang; Zhenqing Ye; Kathryn E. Beckermann; Yue Wu; James W. Jenkins; Peter J. Siska; Benjamin G. Vincent; Y. S. Prakash; Tobias Peikert; Brian T. Edelson; Reshma Taneja; Mark H. Kaplan; Jeffrey C. Rathmell; Haidong Dong; Taro Hitosugi; Jie Sun

doi:10.1016/j.immuni.2019.08.013

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8⁺ T Cell Fitness and Functionality

Chaofan Li
, Bibo Zhu
, Young Min Son
, Zheng Wang
, Li Jiang
, Min Xiang
, Zhenqing Ye
, Kathryn E. Beckermann
, Yue Wu
, James W. Jenkins
, Peter J. Siska
, Benjamin G. Vincent
, Y. S. Prakash
, Tobias Peikert
, Brian T. Edelson
, Reshma Taneja
, Mark H. Kaplan
, Jeffrey C. Rathmell
, Haidong Dong
, Taro Hitosugi

Jie Sun

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

The molecular regulation of CD8⁺ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.

Original language	English (US)
Pages (from-to)	491-507.e7
Journal	Immunity
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2019.08.013
State	Published - Sep 17 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bhlhe40
PD-L1
Tubastatin A
acetate
epigenetic
metabolism
mitochondria
tissue resident memory T cell
tumor-infiltrating lymphocytes

Publisher link

10.1016/j.immuni.2019.08.013

Find It

Find It at U of M Libraries

Cite this

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., ... Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8⁺ T Cell Fitness and Functionality. Immunity, 51(3), 491-507.e7. https://doi.org/10.1016/j.immuni.2019.08.013

Li, C, Zhu, B, Son, YM, Wang, Z, Jiang, L, Xiang, M, Ye, Z, Beckermann, KE, Wu, Y, Jenkins, JW, Siska, PJ, Vincent, BG, Prakash, YS, Peikert, T, Edelson, BT, Taneja, R, Kaplan, MH, Rathmell, JC, Dong, H, Hitosugi, T & Sun, J 2019, 'The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8⁺ T Cell Fitness and Functionality', Immunity, vol. 51, no. 3, pp. 491-507.e7. https://doi.org/10.1016/j.immuni.2019.08.013

@article{f68f585711014300919dbd1f5ef5e0c0,

title = "The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality",

abstract = "The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.",

keywords = "Bhlhe40, PD-L1, Tubastatin A, acetate, epigenetic, metabolism, mitochondria, tissue resident memory T cell, tumor-infiltrating lymphocytes",

author = "Chaofan Li and Bibo Zhu and Son, \{Young Min\} and Zheng Wang and Li Jiang and Min Xiang and Zhenqing Ye and Beckermann, \{Kathryn E.\} and Yue Wu and Jenkins, \{James W.\} and Siska, \{Peter J.\} and Vincent, \{Benjamin G.\} and Prakash, \{Y. S.\} and Tobias Peikert and Edelson, \{Brian T.\} and Reshma Taneja and Kaplan, \{Mark H.\} and Rathmell, \{Jeffrey C.\} and Haidong Dong and Taro Hitosugi and Jie Sun",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "17",

doi = "10.1016/j.immuni.2019.08.013",

language = "English (US)",

volume = "51",

pages = "491--507.e7",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

AU - Li, Chaofan

AU - Zhu, Bibo

AU - Son, Young Min

AU - Wang, Zheng

AU - Jiang, Li

AU - Xiang, Min

AU - Ye, Zhenqing

AU - Beckermann, Kathryn E.

AU - Wu, Yue

AU - Jenkins, James W.

AU - Siska, Peter J.

AU - Vincent, Benjamin G.

AU - Prakash, Y. S.

AU - Peikert, Tobias

AU - Edelson, Brian T.

AU - Taneja, Reshma

AU - Kaplan, Mark H.

AU - Rathmell, Jeffrey C.

AU - Dong, Haidong

AU - Hitosugi, Taro

AU - Sun, Jie

PY - 2019/9/17

Y1 - 2019/9/17

N2 - The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.

AB - The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.

KW - Bhlhe40

KW - PD-L1

KW - Tubastatin A

KW - acetate

KW - epigenetic

KW - metabolism

KW - mitochondria

KW - tissue resident memory T cell

KW - tumor-infiltrating lymphocytes

UR - https://www.scopus.com/pages/publications/85071643836

UR - https://www.scopus.com/pages/publications/85071643836#tab=citedBy

U2 - 10.1016/j.immuni.2019.08.013

DO - 10.1016/j.immuni.2019.08.013

M3 - Article

C2 - 31533057

AN - SCOPUS:85071643836

SN - 1074-7613

VL - 51

SP - 491-507.e7

JO - Immunity

JF - Immunity

IS - 3

ER -