The three-body problem of therapy with induced pluripotent stem cells

Jakub Tolar, John A. McGrath

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.

Original languageEnglish (US)
Article number15
JournalGenome medicine
Issue number1
StatePublished - Feb 20 2015

Bibliographical note

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© 2015 Tolar and McGrath. licensee BioMed Central.


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