The thermophilic yeast Hansenula polymorpha does not require trehalose synthesis for growth at high temperatures but does for normal acquisition of thermotolerance

Anke Reinders, Ivano Romano, Andres Wiemken, Claudio De Virgilio

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The TPS1 gene from Hansenula polymorpha, which encodes trehalose-6- phosphate (Tre6P) synthase, has been isolated and characterized. The deletion of TPS1 rendered H. polymorpha cells incapable of trehalose synthesis under conditions where wild-type cells normally accumulate high levels of trehalose. Interestingly, the loss of Tre6P synthase did not cause any obvious growth defects on a glucose-containing medium, even at high temperatures, but seriously compromised the cells' ability to acquire thermotolerance.

Original languageEnglish (US)
Pages (from-to)4665-4668
Number of pages4
JournalJournal of bacteriology
Volume181
Issue number15
DOIs
StatePublished - Aug 1999

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