The thermally tuned tandem column approach to optimizing selectivity in HPLC

Yun Mao, Peter W Carr

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The authors describe the thermally tuned tandem column concept for the optimization of selectivity in liquid chromatography by effectively continuously adjusting the stationary phase. They serially connected two columns with distinctly different chromatographic selectivities (band spacings) and used independent temperature control for the columns. They tuned the overall selectivity of the tandem column set by individually adjusting the two column temperatures. The authors compare thermally tuned tandem column separations with some single-column optimization strategies, including the variation of temperature, eluent type, eluent composition, and simultaneously varying the temperature and eluent composition.

Original languageEnglish (US)
Pages (from-to)150-167
Number of pages18
JournalLC-GC North America
Volume21
Issue number2
StatePublished - Feb 1 2003

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