The therapeutic utility of lung irradiation for Hodgkin's disease patients with large mediastinal masses

Chung K.K. Lee, Clara D. Bloomfield, Anne I. Goldman, Mark E. Nesbit, Seymour H. Levitt

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26 Scopus citations

Abstract

Since Hodgkin's disease patients with large mediastinal masses frequently relapse in the intrathoracic area after regular mantle field irradiation, the feasibility and utility of low dose lung irradiation as an initial part of the supradiaphragmatic field was examined. Fifteen newly diagnosed patients with Hodgkin's disease and large mediastinal masses were treated with 1000-2000 rad to the lung as a part of extended field radiotherapy. All patients received radiotherapy aloe. Results of treatment were compared with those in 20 similar patients who were treated only with extended field irradiation. With a minimum follow-up of 24 months, only 2 patients (13%) who received lung irradiation have recurred and only one of these recurred in the Lung. In contrast 15 (79%) of the 19 complete responders who were treated without lung irradiation had relapsed by 24 months, 9 in the intrathoracic region. Recurrence-free survival was significantly longer in patients who received Lung irradiation. No increased frequency in serious complications has been experienced to date with low dose whole lung irradiation, compared with regular mantle field treatment. This study suggests that lung irradiation may be a feasible alternative to adjuvant combination chemotherapy when treating patients with Hodgkin's disease and large mediastinal masses.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume7
Issue number2
DOIs
StatePublished - Feb 1981

Bibliographical note

Funding Information:
grant no. CA-15548 from the National Cancer Institute, the Masonic Hospital Fund, Inc., and the Minnesota Medical Foundation. Reprint requests to: Dr. C. K. K. Lee, Department of Therapeutic Radiology, Box 494, University Hospitals, Minneapolis, MN 55455. Accepted for publication 20 October 1980.

Funding Information:
Presented in part at the annual meeting of the American Society of Therapeutic Radiologists, October 26, 1979, New Orleans, LA. *Department of Therapeutic Radiology. *Section of Medical Oncology, Department of Medicine. $Division of Biometry. SDepartment of Pediatrics. This work was supported in part by Public Health Service

Keywords

  • Hodgkin's disease
  • Iung irradiation
  • Large mediastinal mass

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