The TCR ADAPts to integrin-mediated cell adhesion

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Adapter proteins regulate leukocyte signal transduction through recruitment of effector molecules to multiprotein complexes. Recent studies in Adhesion and Degranulation promoting Adapter Protein (ADAP)-deficient mice have established that the cytoplasmic phosphoprotein ADAP is required for optimal, mature T-cell proliferation. Furthermore, ADAP plays a key role in T-cell antigen receptor (TCR)-mediated 'inside out' signaling leading to integrin activation and to enhanced cellular adhesion to integrin ligands. ADAP associates physically with molecules known to play roles in the regulation of TCR-stimulated actin polymerization. These associations support the hypothesis that ADAP functions in actin cytoskeletal reorganization leading to cellular adhesion and activation.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalImmunological Reviews
StatePublished - Apr 2003


Dive into the research topics of 'The TCR ADAPts to integrin-mediated cell adhesion'. Together they form a unique fingerprint.

Cite this