The sweating deficiency in diabetes mellitus: Methods of quantitation and clinical correlation

William R. Kennedy, Manabu Sakuta, David Sutherland, Frederick C. Goetz

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A method that measures the amount of sweat evaporating from the skin was used to quantitate the sweating deficiency that accompanies diabetic neuropathy. The decreased amount of sweat secreted after pilocarpine stimulation was proportional to the reduction in number of excitable sweat glands, and to the decrease in water measured by the summed volume of all sweat droplets secreted. The results also correlated favorably with the degree of sensory loss to painful stimuli, but not to the alpha motor nerve conduction velocity or motor axon loss evaluated by muscle action potentials evoked from foot muscles. Respiratory-cardiovascular reflexes, as measured by the Valsalva ratio, were always abnormal in patients with demonstrated sweating deficiency and often in patients with normal sweat function.

Original languageEnglish (US)
Pages (from-to)758-763
Number of pages6
JournalNeurology
Volume34
Issue number6
DOIs
StatePublished - Jun 1984

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