The suitability of common compressibility equations for characterizing plasticity of diverse powders

Shubhajit Paul, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The analysis of powder compressibility data yields useful information for characterizing compaction behavior and mechanical properties of powders, especially plasticity. Among the many compressibility equations proposed in powder compaction research, the Heckel equation and the Kawakita equation are the most commonly used, despite their known limitations. Systematic evaluation of the performance in analyzing compressibility data suggested the Kuentz-Leuenberger equation is superior to both the Heckel equation and the Kawakita equation for characterizing plasticity of powders exhibiting a wide range of mechanical properties.

Original languageEnglish (US)
Pages (from-to)124-130
Number of pages7
JournalInternational journal of pharmaceutics
Volume532
Issue number1
DOIs
StatePublished - Oct 30 2017

Keywords

  • Compressibility
  • Hardness
  • Heckel equation
  • Kawakita equation
  • Kuentz-Leuenberger equation
  • Plasticity
  • Tableting

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