The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage

Blessing N R Jaja, Daniel Attalla, R. Loch Macdonald, Tom A. Schweizer, Michael D. Cusimano, Nima Etminan, Daniel Hanggi, David Hasan, S. Claiborne Johnston, Peter Le Roux, Benjamin Lo, Ada Louffat-Olivares, Stephan Mayer, Andrew Molyneux, Adam Noble, Audrey Quinn, Thomas Schenk, Julian Spears, Jeffrey Singh, Michael ToddJames Torner, Ming Tseng, William van den Bergh, Mervyn D I Vergouwen, George K C Wong

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.

Original languageEnglish (US)
Pages (from-to)551-559
Number of pages9
JournalNeurocritical Care
Issue number3
StatePublished - Dec 2014

Bibliographical note

Funding Information:
Acknowledgments Funded by a grant from the Canadian Institutes for Health Research.

Publisher Copyright:
© 2014, Springer Science+Business Media New York.


  • Cerebrovascular disease
  • Clinical trials
  • Database
  • Intracranial aneurysm
  • Stroke
  • Subarachnoid hemorrhage


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