Abstract
Biomolecules have been thoroughly investigated in a multitude of solvents historically in order to accentuate or modulate their superlative properties in an array of applications. Ionic liquids have been extensively explored over the last two decades as potential replacements for traditional organic solvents, however, they are sometimes associated with a number of limitations primarily related to cost, convenience, accessibility, and/or sustainability. One potential solvent which is gaining considerable traction in recent years is the so-called deep eutectic solvent which holds a number of striking advantages, including biodegradability, inherently low toxicity, and a facile, low-cost, and solventless preparation from widely available natural feedstocks. In this review, we highlight recent progress and insights into biomolecular behavior within deep eutectic solvent-containing systems, including discussions of their demonstrated utility and prospects for the biostabilization of proteins and nucleic acids, free enzyme and whole-cell biocatalysis, various extraction processes (e.g., aqueous biphasic systems, nanosupported separations), drug solubilization, lignocellulose biomass treatment, and targeted therapeutic drug delivery. All indications point to the likelihood that these emerging solvents have the capacity to satisfy the requirements of environmental responsibility while unlocking biomolecular proficiency in established biomedical and biotechnological pursuits as well as a number of academic and industrial ventures not yet explored.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 536-566 |
| Number of pages | 31 |
| Journal | Journal of Materials Chemistry B |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 21 2021 |
| Externally published | Yes |
Bibliographical note
Funding Information:H. Z. acknowledges the Donors of the American Chemical Society Petroleum Research Fund (PRF# 60077-ND4) for support of this research. K. R. M.-K. is supported by the National Science Foundation under Grant No. CHE-1665157.
Funding Information:
Hua Zhao studied chemistry (BS) and chemical engineering (MS) at Tianjin University before he earned his PhD degree from New Jersey Institute of Technology and completed post-doctoral training at Rutgers University. His doctoral work focused on the synthesis and enzymatic resolu- tion of amino acids in aqueous ionic liquids. He is currently Professor of Chemistry and Department Chair at University of Northern Colorado. His research interests include functionalization of ionic liquids for biocatalysis, asymmetric carbon–carbon bond formation, enzymatic polyester synthesis, enzymatic liquefaction of coal, and the synthesis of medicinal molecules. His research has been supported by NSF, ACS-PRF, and NIH.
Publisher Copyright:
© The Royal Society of Chemistry.