The structure of the most studied DNA fragment changes under the influence of ions: A new packing of d(CGCGAATTCGCG)

Jie Liu; Lucy Malinina; Tam Huynh-Dinh; Juan A. Subirana

doi:10.1016/S0014-5793(98)01295-2

The structure of the most studied DNA fragment changes under the influence of ions: A new packing of d(CGCGAATTCGCG)

Jie Liu, Lucy Malinina, Tam Huynh-Dinh, Juan A. Subirana

The Hormel Institute

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca²⁺. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers. Copyright (C) 1998 Federation of European Biochemical Societies.

Original language	English (US)
Pages (from-to)	211-214
Number of pages	4
Journal	FEBS Letters
Volume	438
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(98)01295-2
State	Published - Nov 6 1998

Bibliographical note

Funding Information:
We are thankful to V. Tereshko and G. Minasov for advice and discussion. This work is supported by a grant (PB93-1067) and a fellowship (J.L.) from the Ministerio de Educación y Cultura.

Keywords

B-DNA structure
Calcium ion
Oligonucleotide
X-ray crystallography

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10.1016/S0014-5793(98)01295-2

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abstract = "The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers. Copyright (C) 1998 Federation of European Biochemical Societies.",

keywords = "B-DNA structure, Calcium ion, Oligonucleotide, X-ray crystallography",

author = "Jie Liu and Lucy Malinina and Tam Huynh-Dinh and Subirana, {Juan A.}",

note = "Funding Information: We are thankful to V. Tereshko and G. Minasov for advice and discussion. This work is supported by a grant (PB93-1067) and a fellowship (J.L.) from the Ministerio de Educaci{\'o}n y Cultura.",

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AU - Malinina, Lucy

AU - Huynh-Dinh, Tam

AU - Subirana, Juan A.

N1 - Funding Information: We are thankful to V. Tereshko and G. Minasov for advice and discussion. This work is supported by a grant (PB93-1067) and a fellowship (J.L.) from the Ministerio de Educación y Cultura.

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Y1 - 1998/11/6

N2 - The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers. Copyright (C) 1998 Federation of European Biochemical Societies.

AB - The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers. Copyright (C) 1998 Federation of European Biochemical Societies.

KW - B-DNA structure

KW - Calcium ion

KW - Oligonucleotide

KW - X-ray crystallography

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The structure of the most studied DNA fragment changes under the influence of ions: A new packing of d(CGCGAATTCGCG)

Abstract

Bibliographical note

Keywords

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