The structure of the most studied DNA fragment changes under the influence of ions: A new packing of d(CGCGAATTCGCG)

Jie Liu, Lucy Malinina, Tam Huynh-Dinh, Juan A. Subirana

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalFEBS Letters
Volume438
Issue number3
DOIs
StatePublished - Nov 6 1998

Keywords

  • B-DNA structure
  • Calcium ion
  • Oligonucleotide
  • X-ray crystallography

Fingerprint Dive into the research topics of 'The structure of the most studied DNA fragment changes under the influence of ions: A new packing of d(CGCGAATTCGCG)'. Together they form a unique fingerprint.

  • Cite this