The stability of diagnosis with an application to bipolar II disorder

John P. Rice; Patricia McDonald-Scott; Jean Endicott; William Coryell; William M. Grove; Martin B. Keller; Debby Altis

doi:10.1016/0165-1781(86)90121-6

The stability of diagnosis with an application to bipolar II disorder

John P. Rice, Patricia McDonald-Scott, Jean Endicott, William Coryell, William M. Grove, Martin B. Keller, Debby Altis

Psychology (Twin Cities)

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

A temporal stability study (where independent diagnostic interviews are conducted at widely separated time points) is discussed and compared to a test/retest reliability study. We introduce a new battery of statistics, based on the sensitivity, specificity, and true base rate of a disorder, that qualifies either reliability or stability over time, and provide a table that relates these underlying parameters to the opening characteristics of the battery. We analyze data on 50 relatives who participated in the family study component of the National Institute of Mental Health's collaborative "Psychobiology Depression Program". The subjects received an interview 5 years after their initial evaluation by raters without knowledge of the initial assessment. The stability of mania, hypomania, major depression, and alcoholism is considered. Although the kappa coefficient for hypomania was small (0.09), all diagnoses of hypomania in the relatives occured in the families of bipolar probands, suggesting that the low value of kappa isdue to a low sensitivity rather than to a low specificity. This is compatible with earlier findings and demonstrates the value of multiple independent assessments when studying this disorder.

Original language	English (US)
Pages (from-to)	285-296
Number of pages	12
Journal	Psychiatry Research
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0165-1781(86)90121-6
State	Published - Dec 1986

Bibliographical note

Funding Information:
Acknowledgments. This study was completed with the participation of the collaborative program investigators:G .L. Klerman, M.D. (Chairperson) (Boston); R.M.A. Hirschfeld, M.D. (Project Director and Co-Chairperson), and P. Griffith, Ph.D. (Rockville, MD); M.B. Keller, M.D., and P. Lavori, Ph.D. (Boston); J.A. Fawcett, M.D., and W.A. Scheftner, M.D. (Chicago); N.C. Andreasen, M.D., W. Coryell, M.D., G. Winokur, M.D., and T. Wasek, B.A. (Iowa City); J. Endicott, Ph.D., P. McDonald Scott, M.A., and J.E. Loth, M.S. W. (New York); J. Rice, Ph.D., T. Reich, M.D., and D. Altis, B.S. (St. Louis). Other contributors include: P.J. Clayton, M.D., J. Croughan, M.D., M.M. Katz, Ph.D., E. Robins, M.D., R.W. Shapiro, M.D., and R. Spitzer, M.D. The research reported was supported, in part, by USPHS grants M H-25430, M H-37685, M H-3 1302,a nd AA-03539.

Keywords

Stability
bipolar II
kappa
reliability
test/retest

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/0165-1781(86)90121-6

Find It

Find It at U of M Libraries

Cite this

@article{75efc66ecddb4ce7b9e1dd1596687531,

title = "The stability of diagnosis with an application to bipolar II disorder",

abstract = "A temporal stability study (where independent diagnostic interviews are conducted at widely separated time points) is discussed and compared to a test/retest reliability study. We introduce a new battery of statistics, based on the sensitivity, specificity, and true base rate of a disorder, that qualifies either reliability or stability over time, and provide a table that relates these underlying parameters to the opening characteristics of the battery. We analyze data on 50 relatives who participated in the family study component of the National Institute of Mental Health's collaborative {"}Psychobiology Depression Program{"}. The subjects received an interview 5 years after their initial evaluation by raters without knowledge of the initial assessment. The stability of mania, hypomania, major depression, and alcoholism is considered. Although the kappa coefficient for hypomania was small (0.09), all diagnoses of hypomania in the relatives occured in the families of bipolar probands, suggesting that the low value of kappa isdue to a low sensitivity rather than to a low specificity. This is compatible with earlier findings and demonstrates the value of multiple independent assessments when studying this disorder.",

keywords = "Stability, bipolar II, kappa, reliability, test/retest",

author = "Rice, {John P.} and Patricia McDonald-Scott and Jean Endicott and William Coryell and Grove, {William M.} and Keller, {Martin B.} and Debby Altis",

note = "Funding Information: Acknowledgments. This study was completed with the participation of the collaborative program investigators:G .L. Klerman, M.D. (Chairperson) (Boston); R.M.A. Hirschfeld, M.D. (Project Director and Co-Chairperson), and P. Griffith, Ph.D. (Rockville, MD); M.B. Keller, M.D., and P. Lavori, Ph.D. (Boston); J.A. Fawcett, M.D., and W.A. Scheftner, M.D. (Chicago); N.C. Andreasen, M.D., W. Coryell, M.D., G. Winokur, M.D., and T. Wasek, B.A. (Iowa City); J. Endicott, Ph.D., P. McDonald Scott, M.A., and J.E. Loth, M.S. W. (New York); J. Rice, Ph.D., T. Reich, M.D., and D. Altis, B.S. (St. Louis). Other contributors include: P.J. Clayton, M.D., J. Croughan, M.D., M.M. Katz, Ph.D., E. Robins, M.D., R.W. Shapiro, M.D., and R. Spitzer, M.D. The research reported was supported, in part, by USPHS grants M H-25430, M H-37685, M H-3 1302,a nd AA-03539.",

year = "1986",

month = dec,

doi = "10.1016/0165-1781(86)90121-6",

language = "English (US)",

volume = "19",

pages = "285--296",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "4",

}

TY - JOUR

T1 - The stability of diagnosis with an application to bipolar II disorder

AU - Rice, John P.

AU - McDonald-Scott, Patricia

AU - Endicott, Jean

AU - Coryell, William

AU - Grove, William M.

AU - Keller, Martin B.

AU - Altis, Debby

N1 - Funding Information: Acknowledgments. This study was completed with the participation of the collaborative program investigators:G .L. Klerman, M.D. (Chairperson) (Boston); R.M.A. Hirschfeld, M.D. (Project Director and Co-Chairperson), and P. Griffith, Ph.D. (Rockville, MD); M.B. Keller, M.D., and P. Lavori, Ph.D. (Boston); J.A. Fawcett, M.D., and W.A. Scheftner, M.D. (Chicago); N.C. Andreasen, M.D., W. Coryell, M.D., G. Winokur, M.D., and T. Wasek, B.A. (Iowa City); J. Endicott, Ph.D., P. McDonald Scott, M.A., and J.E. Loth, M.S. W. (New York); J. Rice, Ph.D., T. Reich, M.D., and D. Altis, B.S. (St. Louis). Other contributors include: P.J. Clayton, M.D., J. Croughan, M.D., M.M. Katz, Ph.D., E. Robins, M.D., R.W. Shapiro, M.D., and R. Spitzer, M.D. The research reported was supported, in part, by USPHS grants M H-25430, M H-37685, M H-3 1302,a nd AA-03539.

PY - 1986/12

Y1 - 1986/12

N2 - A temporal stability study (where independent diagnostic interviews are conducted at widely separated time points) is discussed and compared to a test/retest reliability study. We introduce a new battery of statistics, based on the sensitivity, specificity, and true base rate of a disorder, that qualifies either reliability or stability over time, and provide a table that relates these underlying parameters to the opening characteristics of the battery. We analyze data on 50 relatives who participated in the family study component of the National Institute of Mental Health's collaborative "Psychobiology Depression Program". The subjects received an interview 5 years after their initial evaluation by raters without knowledge of the initial assessment. The stability of mania, hypomania, major depression, and alcoholism is considered. Although the kappa coefficient for hypomania was small (0.09), all diagnoses of hypomania in the relatives occured in the families of bipolar probands, suggesting that the low value of kappa isdue to a low sensitivity rather than to a low specificity. This is compatible with earlier findings and demonstrates the value of multiple independent assessments when studying this disorder.

AB - A temporal stability study (where independent diagnostic interviews are conducted at widely separated time points) is discussed and compared to a test/retest reliability study. We introduce a new battery of statistics, based on the sensitivity, specificity, and true base rate of a disorder, that qualifies either reliability or stability over time, and provide a table that relates these underlying parameters to the opening characteristics of the battery. We analyze data on 50 relatives who participated in the family study component of the National Institute of Mental Health's collaborative "Psychobiology Depression Program". The subjects received an interview 5 years after their initial evaluation by raters without knowledge of the initial assessment. The stability of mania, hypomania, major depression, and alcoholism is considered. Although the kappa coefficient for hypomania was small (0.09), all diagnoses of hypomania in the relatives occured in the families of bipolar probands, suggesting that the low value of kappa isdue to a low sensitivity rather than to a low specificity. This is compatible with earlier findings and demonstrates the value of multiple independent assessments when studying this disorder.

KW - Stability

KW - bipolar II

KW - kappa

KW - reliability

KW - test/retest

UR - http://www.scopus.com/inward/record.url?scp=0022970607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022970607&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(86)90121-6

DO - 10.1016/0165-1781(86)90121-6

M3 - Article

C2 - 3809326

AN - SCOPUS:0022970607

SN - 0165-1781

VL - 19

SP - 285

EP - 296

JO - Psychiatry Research

JF - Psychiatry Research

IS - 4

ER -

The stability of diagnosis with an application to bipolar II disorder

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this